{"id":"W1975009723","doi":"10.1007/s11010-013-1933-y","title":"Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep −/− mice","year":2014,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; British Heart Foundation","keywords":"Bile Salt Export Pump; Lithocholic acid; Cholestasis; CYP3A; Cytochrome P450; Hydroxylation; Biology; Bile acid; Endocrinology; Internal medicine; CYP8B1; Glucuronosyltransferase; CYP27A1; Progressive familial intrahepatic cholestasis; Cholic acid; Biochemistry; Microsome; Enzyme; Metabolism; Gene; Transporter; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003900086,0.001503602,0.0008902615,0.002938166,0.0005684535,0.001100119,0.0007627092,0.001675564,0.008599345],"category_scores_gemma":[0.0005471115,0.001076126,0.0008154794,0.0008277443,0.00186058,0.001336597,0.000678332,0.002813007,0.001809653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005096559,"about_ca_system_score_gemma":0.0003075753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009805663,"about_ca_topic_score_gemma":0.0009545052,"domain_scores_codex":[0.9992549,0.00007097125,0.0001180617,0.0002294802,0.0002083863,0.0001182959],"domain_scores_gemma":[0.9987918,0.0001373269,0.0005049718,0.00012429,0.00009386457,0.0003478245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009318212,0.0001416163,0.0004237601,0.00004985271,0.00002546662,0.0003781548,0.00004503056,0.00009102924,0.9964949,0.0002932036,0.00009514306,0.001030082],"study_design_scores_gemma":[0.000243021,0.0008795408,0.02008109,0.0000473459,0.0002148354,0.003116923,0.0003750244,0.001160805,0.968766,0.0007091597,0.004350689,0.00005558848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857738,0.0007316177,0.006219871,0.0005014201,0.0001568802,0.0000590038,0.004566749,0.0004595323,0.001531089],"genre_scores_gemma":[0.9514307,0.002017668,0.0068931,0.0004878007,0.0001622111,0.0004047849,0.006344879,0.00106195,0.03119692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008599345,"threshold_uncertainty_score":0.02876765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002859495357998126,"score_gpt":0.1885174505848774,"score_spread":0.1856579552268793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}