{"id":"W1975009723","doi":"10.1007/s11010-013-1933-y","title":"Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep −/− mice","year":2014,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; British Heart Foundation","keywords":"Bile Salt Export Pump; Lithocholic acid; Cholestasis; CYP3A; Cytochrome P450; Hydroxylation; Biology; Bile acid; Endocrinology; Internal medicine; CYP8B1; Glucuronosyltransferase; CYP27A1; Progressive familial intrahepatic cholestasis; Cholic acid; Biochemistry; Microsome; Enzyme; Metabolism; Gene; Transporter; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001501448,0.0001685909,0.0003588358,0.00005476315,0.00003177593,0.000009786651,0.00004600083,0.0001732071,0.00001670829],"category_scores_gemma":[0.00002610278,0.0001429976,0.00005210172,0.00009248888,0.0001101664,0.00002158374,0.00003316425,0.0001393782,4.115913e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007333795,"about_ca_system_score_gemma":0.00001672257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008009502,"about_ca_topic_score_gemma":8.439583e-7,"domain_scores_codex":[0.9990684,0.00003179163,0.000244464,0.0003185261,0.0001499842,0.0001868394],"domain_scores_gemma":[0.9995132,0.00001162123,0.00008821477,0.0002131917,0.00002904656,0.0001447456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006548596,0.00005530806,0.001007654,0.0006563506,0.00002182029,0.00007660049,0.00009990412,3.59817e-7,0.9977311,0.00006793968,0.000006418541,0.0002110497],"study_design_scores_gemma":[0.001544943,0.00004019039,0.003089926,0.0004351116,0.0001084724,0.00003890126,0.0001715873,0.0000652685,0.9939857,0.0002983199,0.00007161181,0.0001499863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850283,0.01375948,0.0005676899,0.0001050387,0.00002314809,0.0001429327,0.00000757964,0.00001599225,0.0003498676],"genre_scores_gemma":[0.9990104,0.0001164023,0.0005557995,0.00005411749,0.00001931725,0.000008924129,0.00004974333,0.00001967746,0.0001656161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01398213,"threshold_uncertainty_score":0.5831273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002859495357998126,"score_gpt":0.1885174505848774,"score_spread":0.1856579552268793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}