{"id":"W1975032319","doi":"10.1016/s0006-2952(00)00249-5","title":"Transcriptional suppression of cytochrome P450 2C11 gene expression by 3-methylcholanthrene","year":2000,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Methylcholanthrene; Cytochrome P450; Transcription (linguistics); Gene expression; Biology; In vivo; Messenger RNA; Enzyme inducer; Gene; Carcinogen; Molecular biology; Internal medicine; Chemistry; Endocrinology; Enzyme; Metabolism; Biochemistry; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002584974,0.0005477878,0.0003753552,0.0005480445,0.0003877059,0.0006471336,0.0002612588,0.00040827,0.00269757],"category_scores_gemma":[0.0003815022,0.00034459,0.0006768365,0.0003248076,0.0006360451,0.0002337005,0.0003890822,0.0008375383,0.0007158414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007381366,"about_ca_system_score_gemma":0.0005785606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002904338,"about_ca_topic_score_gemma":0.003849963,"domain_scores_codex":[0.9995932,0.00007451013,0.00003494215,0.00008693837,0.00007697841,0.0001334737],"domain_scores_gemma":[0.9995074,0.0001842595,0.00007795834,0.00009974123,0.00004808625,0.00008254231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003665469,0.00004713637,0.0002485679,0.00001584036,0.000005815124,0.00007412863,0.00002301355,0.00008736995,0.9981418,0.0002006478,0.00005218322,0.0007369481],"study_design_scores_gemma":[0.00001641243,0.0001372551,0.003000594,0.000003185757,0.000008423566,0.0001062883,0.00004242583,0.0005174151,0.9951592,0.00004216196,0.0009617562,0.000004916118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914721,0.001118254,0.003364828,0.0004174352,0.0001146275,0.00004864292,0.0008633857,0.000185017,0.002415796],"genre_scores_gemma":[0.9929686,0.0003792534,0.0007852922,0.00006720248,0.00002062837,0.00003286651,0.0007239558,0.00004103271,0.004981135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002904338,"threshold_uncertainty_score":0.009024203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05556530959790702,"score_gpt":0.4018804836958368,"score_spread":0.3463151740979298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}