{"id":"W1975071492","doi":"10.1385/mb:31:3:187","title":"A Novel In Vitro Transcription Method for Producing siRNAs Without Specific Sequence Requirements","year":2005,"lang":"en","type":"article","venue":"Molecular Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Small interfering RNA; Trans-acting siRNA; RNA interference; Biology; Transcription (linguistics); RNA silencing; Gene silencing; RNA; RNase H; RNase P; Oligonucleotide; Molecular biology; DNA; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003123118,0.0002164989,0.0002209246,0.0001922816,0.00004970521,0.0000194399,0.000340792,0.0004524502,0.000005390215],"category_scores_gemma":[0.00006511099,0.0002297102,0.0001152886,0.0001788909,0.00008703898,0.000008997154,0.00007133959,0.0001703784,0.00001049072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005718204,"about_ca_system_score_gemma":0.00004835763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003061642,"about_ca_topic_score_gemma":0.00006213941,"domain_scores_codex":[0.9983913,0.00004089063,0.0003190522,0.0007280565,0.0001060525,0.0004146264],"domain_scores_gemma":[0.9992585,0.000004670735,0.00008787969,0.0005366669,0.00007094153,0.0000413276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002310271,0.00009421678,0.00002546993,0.00001342852,0.00003221289,0.000004526955,0.00003932281,0.0002184892,0.9641147,0.0001807776,0.00009448536,0.03495135],"study_design_scores_gemma":[0.0009416802,0.0002821861,0.00003858346,0.00001997232,0.0000127265,0.00004972731,0.00003942321,0.0007500689,0.9696586,0.0001253938,0.02783327,0.0002484124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5649574,0.0006325415,0.4322184,0.001565832,0.00009265749,0.0004126305,0.00002097383,0.00003202412,0.00006754592],"genre_scores_gemma":[0.8586847,0.0001461328,0.1401065,0.0005676674,0.00009897461,0.0001160573,0.0001077916,0.00003187503,0.0001403003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2937273,"threshold_uncertainty_score":0.9367312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03398083903826116,"score_gpt":0.3077831833486565,"score_spread":0.2738023443103953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}