{"id":"W1975074016","doi":"10.1016/j.dnarep.2007.05.002","title":"Immunoglobulin gene conversion: Synthesizing antibody diversification and DNA repair","year":2007,"lang":"en","type":"review","venue":"DNA repair","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Cytidine deaminase; Biology; Somatic hypermutation; Activation-induced (cytidine) deaminase; Gene conversion; Gene; Immunoglobulin class switching; Genetics; DNA; Antibody; Computational biology; Mechanism (biology); Recombination; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004959244,0.001646728,0.001471532,0.001289772,0.0003063903,0.001056938,0.00187324,0.002311356,0.002284644],"category_scores_gemma":[0.0003775033,0.0004244247,0.000410311,0.001532456,0.001204807,0.001926331,0.0007585323,0.00251194,0.002920389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007462736,"about_ca_system_score_gemma":0.000836211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003274987,"about_ca_topic_score_gemma":0.0005092655,"domain_scores_codex":[0.9998043,0.00002729754,0.00002499007,0.00005054657,0.00006760369,0.00002524181],"domain_scores_gemma":[0.9998434,0.00006056062,0.00002940683,0.000009767949,0.00003425475,0.00002262853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001398878,0.0001090458,0.00014867,0.006125245,0.00005522663,0.0007355037,0.00003848211,0.0005091431,0.01362131,0.008816266,0.04053423,0.929167],"study_design_scores_gemma":[0.00002344737,0.00007639304,0.0003685568,0.0005158957,0.00005911601,0.003013534,0.00003920551,0.0001446045,0.005817418,0.003938389,0.9859858,0.00001756431],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003454109,0.9934316,0.001687712,0.0005124934,0.001857593,0.000009467098,0.00001766209,0.00003383021,0.002104296],"genre_scores_gemma":[0.002023772,0.9922972,0.001028193,0.0004645147,0.001491127,0.00001883761,0.00006554837,0.000004436741,0.002606391],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002311356,"threshold_uncertainty_score":0.007642925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03443881287375026,"score_gpt":0.288605640901725,"score_spread":0.2541668280279747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}