{"id":"W1975074016","doi":"10.1016/j.dnarep.2007.05.002","title":"Immunoglobulin gene conversion: Synthesizing antibody diversification and DNA repair","year":2007,"lang":"en","type":"review","venue":"DNA repair","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Cytidine deaminase; Biology; Somatic hypermutation; Activation-induced (cytidine) deaminase; Gene conversion; Gene; Immunoglobulin class switching; Genetics; DNA; Antibody; Computational biology; Mechanism (biology); Recombination; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009433341,0.0008139086,0.002046411,0.0004556266,0.0005984489,0.00002792017,0.0005659008,0.001884587,0.0006364469],"category_scores_gemma":[0.0001415283,0.0007098629,0.001142261,0.0003843393,0.0007019733,0.0001396268,0.0005125954,0.0009931729,0.002687235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002114079,"about_ca_system_score_gemma":0.0002073847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001243324,"about_ca_topic_score_gemma":0.000003327295,"domain_scores_codex":[0.9960186,0.0006928914,0.001131316,0.001235108,0.00008779188,0.0008343049],"domain_scores_gemma":[0.9972161,0.0006455373,0.0007252123,0.001227234,0.0001224421,0.00006345694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000412896,0.0008891347,0.0003385899,0.01361094,0.007145954,0.0006086833,0.0005554404,1.579345e-7,0.3330501,0.0009000787,0.03043105,0.612057],"study_design_scores_gemma":[0.0006403992,0.0001841388,0.00004790821,0.001917571,0.001232634,0.0008467623,0.0001370683,0.000001000788,0.006231092,0.000008227894,0.9880192,0.0007340501],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003435455,0.9913424,0.00002752336,0.00003758511,0.00186693,0.0008675148,0.00009878755,0.001006798,0.001316963],"genre_scores_gemma":[0.0009689022,0.9904442,0.0002920831,0.00009934972,0.0001200513,0.00003564408,0.00163757,0.0000848757,0.00631727],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9575881,"threshold_uncertainty_score":0.9995353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03443881287375026,"score_gpt":0.288605640901725,"score_spread":0.2541668280279747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}