{"id":"W1975076291","doi":"10.1089/cbr.2008.0579","title":"Preclinical Assessment of an Anti-EpCAM Immunotoxin: Locoregional Delivery Provides a Safer Alternative to Systemic Administration","year":2009,"lang":"en","type":"article","venue":"Cancer Biotherapy and Radiopharmaceuticals","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"","keywords":"Immunotoxin; Medicine; Systemic administration; SAFER; Epithelial cell adhesion molecule; Administration (probate law); Pharmacology; Cancer; Internal medicine; Immunology; Antibody; Monoclonal antibody; Computer science; Computer security","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003519105,0.0004990277,0.0003629186,0.0002482658,0.0001306293,0.0003166705,0.0003418011,0.0004721853,0.001507861],"category_scores_gemma":[0.0002012176,0.0001213724,0.0001975377,0.0001699323,0.0002979846,0.0003754615,0.0001686556,0.0007607399,0.0002325435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003191166,"about_ca_system_score_gemma":0.0003134843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005297357,"about_ca_topic_score_gemma":0.0006596033,"domain_scores_codex":[0.9998653,0.00002945463,0.00000703068,0.00002531529,0.00003135683,0.00004155112],"domain_scores_gemma":[0.9998354,0.00002797065,0.00006270094,0.00001672509,0.00002467152,0.00003259359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001031613,0.001299185,0.0004707774,0.0001205964,0.00002336414,0.00008477833,0.00002922259,0.0007553267,0.9854006,0.0002214507,0.0001388272,0.01042424],"study_design_scores_gemma":[0.0002209948,0.05195693,0.002512993,0.00001664849,0.0001045476,0.0002996128,0.00003109168,0.00110418,0.9408891,0.00007754569,0.002779222,0.000007149169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917611,0.001190341,0.004991545,0.00007623321,0.00002982729,0.0002528843,0.0001937452,0.00007789641,0.001426454],"genre_scores_gemma":[0.9935654,0.001144003,0.002675976,0.00005672275,0.00001621539,0.0001766565,0.0003193381,0.00001658238,0.002029119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001507861,"threshold_uncertainty_score":0.005044281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03922912368538579,"score_gpt":0.392584855315723,"score_spread":0.3533557316303372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}