{"id":"W1975076291","doi":"10.1089/cbr.2008.0579","title":"Preclinical Assessment of an Anti-EpCAM Immunotoxin: Locoregional Delivery Provides a Safer Alternative to Systemic Administration","year":2009,"lang":"en","type":"article","venue":"Cancer Biotherapy and Radiopharmaceuticals","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"","keywords":"Immunotoxin; Medicine; Systemic administration; SAFER; Epithelial cell adhesion molecule; Administration (probate law); Pharmacology; Cancer; Internal medicine; Immunology; Antibody; Monoclonal antibody; Computer science; Computer security","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000422439,0.0002677847,0.0005059485,0.0001191883,0.0001576553,0.0000330023,0.0002583665,0.0002621668,0.0004363139],"category_scores_gemma":[0.00001615311,0.0002194173,0.0001119527,0.0001365319,0.0002272693,0.0002174048,0.00002652641,0.0003031136,0.00000988834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008314235,"about_ca_system_score_gemma":0.0002368694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000025704,"about_ca_topic_score_gemma":0.000002870134,"domain_scores_codex":[0.9981999,0.0002939239,0.0005787995,0.0004811281,0.0000911678,0.0003550278],"domain_scores_gemma":[0.9992081,0.0001147266,0.0001917593,0.0002753912,0.0001112391,0.00009876189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000932601,0.000394427,0.000548025,0.00003714987,0.0002455054,0.000005620773,0.000304089,0.00003867583,0.9474256,0.002672293,0.00009568714,0.04730032],"study_design_scores_gemma":[0.005472196,0.004284862,0.03558694,0.000415164,0.000137493,0.0001723052,0.0002477277,0.0005615258,0.9386937,0.0002516911,0.01355617,0.0006201856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819089,0.01376345,0.001359466,0.001001812,0.0006436566,0.001049657,0.0001206262,0.00005142869,0.000101063],"genre_scores_gemma":[0.9906288,0.006234493,0.0009055714,0.001752162,0.0001270438,0.00008702898,0.0000298576,0.00001830607,0.0002167841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04668013,"threshold_uncertainty_score":0.894758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03922912368538579,"score_gpt":0.392584855315723,"score_spread":0.3533557316303372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}