{"id":"W1975084695","doi":"10.1016/j.neulet.2012.12.051","title":"Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells","year":2013,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Biochemical effects in animals","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Fundamental Research Funds for the Central Universities; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; National Natural Science Foundation of China","keywords":"Caffeic acid phenethyl ester; Acrolein; Neurotoxicity; Oxidative stress; Chemistry; Caffeic acid; Neuroprotection; Glutathione; Reactive oxygen species; Biochemistry; Protein kinase B; Pharmacology; Antioxidant; Signal transduction; Biology; Toxicity; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001803624,0.0006024922,0.0004447821,0.0003370505,0.000329685,0.0001993028,0.0003046452,0.0004534296,0.001220993],"category_scores_gemma":[0.0002122159,0.0001935945,0.000481954,0.0002908558,0.0002890944,0.0004665834,0.0002127987,0.0005166811,0.00015903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001842404,"about_ca_system_score_gemma":0.0003898078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002966962,"about_ca_topic_score_gemma":0.002756103,"domain_scores_codex":[0.9998868,0.000014474,0.00001214181,0.00001904188,0.00001476907,0.00005278699],"domain_scores_gemma":[0.9998767,0.00001355402,0.00002253,0.00001497803,0.000029536,0.0000426389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001465746,0.00009317453,0.0001769087,0.0001695334,0.00003559281,0.0001884095,0.00007636065,0.00007484999,0.9958472,0.0001127038,0.00006394534,0.001695548],"study_design_scores_gemma":[0.0001383906,0.001465682,0.004027856,0.0000130037,0.0000877162,0.0002325515,0.00008133811,0.0003124769,0.9920676,0.00007489838,0.001485999,0.00001245449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939923,0.003610961,0.0008597417,0.0001228515,0.0000657739,0.00002525834,0.0002503936,0.0000392062,0.001033544],"genre_scores_gemma":[0.9961972,0.001671631,0.0006876529,0.00005217064,0.00002581238,0.00001616129,0.0002746682,0.000006054177,0.001068647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002966962,"threshold_uncertainty_score":0.005899429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009248992265314476,"score_gpt":0.2362096310983178,"score_spread":0.2269606388330033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}