{"id":"W1975090633","doi":"10.1016/j.bmcl.2010.02.060","title":"Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"University of Guelph","keywords":"Chemistry; DNA gyrase; Escherichia coli; Quercetin; In vitro; Stereochemistry; Antibacterial agent; Microbiology; Combinatorial chemistry; Antibiotics; Biochemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001204733,0.0002260823,0.0003864621,0.00004117046,0.0001087124,0.000009867174,0.00017406,0.0002651737,0.0005792741],"category_scores_gemma":[0.0004588221,0.000184771,0.00005039675,0.0001102739,0.0009195193,0.00006266454,0.0000930913,0.0004080705,0.000001976816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002361245,"about_ca_system_score_gemma":0.00008180978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002896739,"about_ca_topic_score_gemma":9.693018e-7,"domain_scores_codex":[0.9985889,0.0001775748,0.0003559146,0.0003385047,0.0002915795,0.0002475349],"domain_scores_gemma":[0.9990442,0.0002496867,0.000255344,0.000154355,0.0001361163,0.0001602996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001231062,0.0002336926,0.03073372,0.0001384294,0.0001337253,0.00001233463,0.0001839333,0.00000245809,0.9666076,0.0000113341,0.0003094196,0.001510199],"study_design_scores_gemma":[0.001180294,0.0000479916,0.08364893,0.00006640879,0.0003043491,0.000106441,0.0002359744,0.0002432902,0.9135939,0.00001577839,0.0003869177,0.0001696636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966379,0.0004599174,0.0001003823,0.002116856,0.0002563382,0.000253032,0.0000433005,0.00001925225,0.000112958],"genre_scores_gemma":[0.9984793,0.0004729536,0.0003553429,0.0004990781,0.0001417954,0.0000133477,0.00001513757,0.00001377153,0.000009283262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05301369,"threshold_uncertainty_score":0.7534742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1576320448530112,"score_gpt":0.3900674770453906,"score_spread":0.2324354321923794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}