{"id":"W1975095265","doi":"10.1002/jhet.23","title":"Synthesis of new 1‐(2‐, 3‐, or 4‐methanesulfonylphenyl)‐2‐[5‐(<i>N</i>‐hydroxypyridin‐2(1<i>H</i>)‐one)]acetylene regioisomers: A search for novel cyclooxygenase and lipoxygenase inhibitors","year":2009,"lang":"en","type":"article","venue":"Journal of Heterocyclic Chemistry","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Structural isomer; Acetylene; Pharmacophore; Stereochemistry; Sonogashira coupling; Moiety; Organic chemistry; Palladium; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000707211,0.0004045671,0.0009790323,0.00009714508,0.0001025661,0.00006058487,0.0004586663,0.0004393286,0.0003656498],"category_scores_gemma":[0.001411108,0.0003009443,0.0005192989,0.0002077469,0.0001398167,0.0002064135,0.00006965996,0.0003923677,0.000001608112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001266843,"about_ca_system_score_gemma":0.0001679527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001633436,"about_ca_topic_score_gemma":0.000001509813,"domain_scores_codex":[0.9969472,0.00003336521,0.001392156,0.0004533822,0.0006865987,0.0004873545],"domain_scores_gemma":[0.9968267,0.0008884053,0.001096779,0.0004202834,0.0002977673,0.0004700363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001586969,0.0005422837,0.0001358313,0.0004500615,0.0001742406,0.00001387044,0.0001341759,0.00002897899,0.9584932,0.000002788543,0.0006956037,0.03774194],"study_design_scores_gemma":[0.002465287,0.0002564804,0.0002593113,0.0007012825,0.0002418145,0.0003381925,0.0003804618,0.0001542707,0.9926238,0.0001629745,0.002058476,0.0003576499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959959,0.00127524,0.0003852614,0.001527228,0.00006497011,0.0001509359,0.00005549698,0.00002963157,0.0005153737],"genre_scores_gemma":[0.9931673,0.0007653247,0.004309425,0.0001642103,0.001135279,0.00001143277,0.00001032037,0.00003502841,0.0004016802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03738429,"threshold_uncertainty_score":0.9999443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05467083065567986,"score_gpt":0.2919885121363345,"score_spread":0.2373176814806547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}