{"id":"W1975100977","doi":"10.1038/gt.2011.11","title":"In vitro and in vivo comparison of viral and cellular internal ribosome entry sites for bicistronic vector expression","year":2011,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; Terry Fox Foundation","keywords":"Internal ribosome entry site; Biology; Translation (biology); Reporter gene; Transfection; Molecular biology; Ribosome; Gene; Cell biology; Virology; Plasmid; Gene expression; Messenger RNA; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001907111,0.000751601,0.0007098243,0.0005992482,0.0004125353,0.001084411,0.0005010088,0.000648401,0.001757812],"category_scores_gemma":[0.001135428,0.0005713993,0.0005564136,0.0005157318,0.0005483177,0.0007364271,0.000342402,0.001335166,0.0007560635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008095573,"about_ca_system_score_gemma":0.0006402721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00138198,"about_ca_topic_score_gemma":0.002002254,"domain_scores_codex":[0.998704,0.000464612,0.0001372236,0.0002019483,0.0002489172,0.0002432155],"domain_scores_gemma":[0.9986413,0.0007745678,0.0001588178,0.0001276117,0.0001867473,0.0001109315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000203741,0.00003122313,0.00005402879,0.00003298964,0.000004301403,0.000008160582,0.00002062322,0.00006701304,0.9989107,0.0001847784,0.00002058355,0.0004618638],"study_design_scores_gemma":[0.000007783809,0.0001311769,0.0003090253,0.000003106229,0.0000154256,0.00003089267,0.00001109232,0.0005169653,0.9985716,0.00001965983,0.0003799668,0.000003279267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623703,0.002584909,0.03075447,0.0001201501,0.0001191008,0.0001010303,0.0007594172,0.0001888691,0.003001745],"genre_scores_gemma":[0.9734385,0.001094368,0.01725196,0.00007114353,0.000032021,0.0001299411,0.003213183,0.0002760147,0.004492892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001907111,"threshold_uncertainty_score":0.01008588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04894365000743112,"score_gpt":0.330901576482045,"score_spread":0.2819579264746139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}