{"id":"W1975100977","doi":"10.1038/gt.2011.11","title":"In vitro and in vivo comparison of viral and cellular internal ribosome entry sites for bicistronic vector expression","year":2011,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; Terry Fox Foundation","keywords":"Internal ribosome entry site; Biology; Translation (biology); Reporter gene; Transfection; Molecular biology; Ribosome; Gene; Cell biology; Virology; Plasmid; Gene expression; Messenger RNA; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000108782,0.00006478491,0.0002008973,0.0001318211,0.00001974574,0.000003530629,0.00003369531,0.00005818075,0.00007855851],"category_scores_gemma":[0.000007876219,0.00005112524,0.00002323125,0.00005275834,0.00007983141,0.00004792285,0.00002438881,0.0001177191,6.78818e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001873681,"about_ca_system_score_gemma":0.00001524365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001163604,"about_ca_topic_score_gemma":0.00001084845,"domain_scores_codex":[0.9995078,0.00003451191,0.0001566905,0.0001158133,0.00004406096,0.0001410761],"domain_scores_gemma":[0.999808,0.00002377135,0.00003357158,0.00009089826,0.00001865548,0.00002511714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001971618,0.0002041904,0.09661303,0.00001694021,0.00001613048,0.000001847185,0.000625622,1.959721e-7,0.8985148,0.000007803708,0.00002940676,0.00199843],"study_design_scores_gemma":[0.002717279,0.0009654446,0.03229807,0.00002985583,0.000003299419,0.000004441513,0.0001061363,0.0002078532,0.9632565,0.0001152856,0.0002535531,0.00004232135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928011,0.006660942,0.0001464488,0.00005186714,0.00003779242,0.0002413178,0.000006001178,0.000004551379,0.00004993835],"genre_scores_gemma":[0.998789,0.0006503793,0.0003813594,0.00002322339,0.00002635727,0.00002324924,0.000004561397,0.000007304209,0.00009457224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06474169,"threshold_uncertainty_score":0.2084827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04894365000743112,"score_gpt":0.330901576482045,"score_spread":0.2819579264746139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}