{"id":"W1975168389","doi":"10.1021/ja0485659","title":"The Mechanism of the Reaction Catalyzed by ADP-β-<scp>l</scp>-<i>g</i><i>lycero</i>-<scp>d</scp>-<i>m</i><i>anno</i>-heptose 6-Epimerase","year":2004,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Heptose; Kinetic isotope effect; Biosynthesis; Cofactor; Stereochemistry; Enzyme; Catalysis; Reaction intermediate; Substrate (aquarium); Epimer; Biochemistry; Deuterium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008775994,0.0004128597,0.0008064607,0.00002120077,0.0004584648,0.00003836236,0.001091424,0.0002339834,0.000003537745],"category_scores_gemma":[0.001543221,0.0002096611,0.001472404,0.0008905057,0.001279276,0.0001264317,0.0003114113,0.001783989,0.000007335055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005510135,"about_ca_system_score_gemma":0.0007752183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000246679,"about_ca_topic_score_gemma":0.000003043008,"domain_scores_codex":[0.9962991,0.000115401,0.00110547,0.0003592901,0.00134921,0.0007715492],"domain_scores_gemma":[0.9948555,0.000988038,0.002305795,0.0008848454,0.0004353151,0.0005304597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009194772,0.0003273262,0.000239248,0.0001145698,0.0002249125,0.000005651867,0.0005105159,0.000002185279,0.931527,0.00003049118,0.06598023,0.0009459763],"study_design_scores_gemma":[0.001999137,0.000214341,0.00034815,0.0002259093,0.0003250224,0.000532959,0.002751899,0.00001111737,0.9540902,0.0007475015,0.03868199,0.00007179662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897137,0.001533823,0.00007369414,0.007158986,0.0005260428,0.0003987888,0.00007117066,0.0000336848,0.0004901121],"genre_scores_gemma":[0.9893876,0.001546491,0.0007814926,0.006369867,0.0008107362,0.00001444611,0.00001603548,0.00006271817,0.001010601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02729824,"threshold_uncertainty_score":0.8549733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006645763050254209,"score_gpt":0.250305079875387,"score_spread":0.2436593168251328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}