{"id":"W1975186629","doi":"10.1073/pnas.1406559111","title":"Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Health Network; Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"GTPase; Phosphorylation; GTPase-activating protein; Proto-oncogene tyrosine-protein kinase Src; Tyrosine; Cell biology; GTP'; Biology; SH3 domain; Tyrosine phosphorylation; Chemistry; Biochemistry; Signal transduction; G protein; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00097946,0.00007198872,0.0001069988,0.00006158375,0.00009167581,0.000007353951,0.0002781014,0.0000853465,0.00000738192],"category_scores_gemma":[0.0004786038,0.00005208548,0.00006695207,0.000272729,0.0004155651,0.00002312493,0.00008510774,0.00005675024,3.327145e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007770784,"about_ca_system_score_gemma":0.00002434353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004859119,"about_ca_topic_score_gemma":6.943088e-8,"domain_scores_codex":[0.9990215,0.000009752778,0.0002046309,0.0001791999,0.0004967191,0.00008820485],"domain_scores_gemma":[0.999262,0.00002072411,0.0004129026,0.00001112872,0.0002693866,0.00002382733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002756304,0.00003753498,0.001635215,0.00004446653,0.000007286464,4.901174e-10,0.00001765334,0.0001013789,0.9920935,0.0043575,0.00006294775,0.001614957],"study_design_scores_gemma":[0.0001611856,0.00007702261,0.02022191,0.00004253609,0.000006892439,0.000001742795,0.000006736702,0.002648794,0.9688993,0.007649852,0.0002273564,0.00005675462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976844,0.0001333948,0.0001559012,0.0006421771,0.00001059091,0.0001490838,0.000006633034,0.000003744445,0.001214072],"genre_scores_gemma":[0.9983307,0.0000097223,0.001455571,0.00006627669,0.00006807801,0.000005213068,5.776404e-7,0.000003313433,0.00006058933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02319428,"threshold_uncertainty_score":0.2123984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02070335428000736,"score_gpt":0.2758677280531308,"score_spread":0.2551643737731235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}