{"id":"W1975186639","doi":"10.1038/bjc.2014.565","title":"A Phase I study of cyclin-dependent kinase inhibitor, AT7519, in patients with advanced cancer: NCIC Clinical Trials Group IND 177","year":2014,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; Hamilton Health Sciences; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Mucositis; Tolerability; Neutropenia; Internal medicine; Pharmacodynamics; Pharmacokinetics; Rash; Febrile neutropenia; Dosing; Cancer; Gastroenterology; Toxicity; Refractory (planetary science); Pharmacology; Response Evaluation Criteria in Solid Tumors; Adverse effect; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009391959,0.00101746,0.001430832,0.0004480206,0.0004319025,0.0006605375,0.0008540783,0.0008974903,0.003548041],"category_scores_gemma":[0.0004666963,0.0002388441,0.0005656133,0.0006686109,0.0006235054,0.0003254675,0.0002285527,0.001806998,0.0006031389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009535654,"about_ca_system_score_gemma":0.002063722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00247886,"about_ca_topic_score_gemma":0.00605421,"domain_scores_codex":[0.999713,0.0001074817,0.00001244434,0.00004630379,0.00005426234,0.00006661288],"domain_scores_gemma":[0.999644,0.00004538922,0.00005384462,0.0000190497,0.00002993591,0.0002077902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5238231,0.05687517,0.01477634,0.002370114,0.001626597,0.0009770463,0.0004927406,0.004459288,0.0953233,0.0008681333,0.01989671,0.2785115],"study_design_scores_gemma":[0.5783129,0.3782082,0.0223353,0.00008924257,0.0005478393,0.0007731278,0.00006904206,0.001648243,0.006474567,0.0002408114,0.01125936,0.00004128355],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779468,0.007892759,0.0008301202,0.0006250936,0.0001167864,0.005756101,0.001999124,0.0001564836,0.004676668],"genre_scores_gemma":[0.9785066,0.004788177,0.00348203,0.001169241,0.0002378695,0.004863142,0.003996758,0.00002750587,0.002928655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003548041,"threshold_uncertainty_score":0.01186931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03146655708732439,"score_gpt":0.3865964881331453,"score_spread":0.3551299310458209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}