{"id":"W1975245996","doi":"10.1016/j.bpj.2011.11.513","title":"Amphipathic Turn Conformations in Linear Tryptophan-Rich Cationic Antimicrobial Peptides: Implications for Rational Design of Novel Antimicrobials","year":2012,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University","funders":"","keywords":"Antimicrobial peptides; Amphiphile; Isothermal titration calorimetry; Chemistry; Peptide; Membrane; Circular dichroism; Antimicrobial; Turn (biochemistry); Tryptophan; Vesicle; Cationic polymerization; Biophysics; Combinatorial chemistry; Lipid bilayer; Alamethicin; Rational design; Stereochemistry; Biochemistry; Amino acid; Nanotechnology; Organic chemistry; Biology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003625965,0.0003015412,0.0003104829,0.0001129816,0.0003038624,0.000536854,0.0003433535,0.0003660305,0.0008160722],"category_scores_gemma":[0.000432535,0.0002112338,0.0002766528,0.00009524293,0.000434499,0.0006064415,0.000319976,0.0008613265,0.000290672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003209748,"about_ca_system_score_gemma":0.0003189022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002321054,"about_ca_topic_score_gemma":0.0003751563,"domain_scores_codex":[0.9999284,0.00001912242,0.000005210622,0.00001023045,0.00001429242,0.00002275316],"domain_scores_gemma":[0.9998808,0.00004725642,0.00002580194,0.000006955329,0.00001500586,0.00002427774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001087237,0.0002306909,0.001415552,0.0002702639,0.00003940698,0.001553399,0.0002412513,0.0324639,0.9266292,0.01528929,0.0004276439,0.0203521],"study_design_scores_gemma":[0.0006096144,0.003197101,0.002887065,0.0001598428,0.0001855772,0.001728715,0.000715185,0.1046891,0.8559413,0.01720868,0.01253322,0.0001446839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766075,0.001585257,0.01904868,0.0003242839,0.00004526205,0.00006272117,0.00006020026,0.00009622792,0.002170019],"genre_scores_gemma":[0.9919212,0.0009955375,0.006322396,0.0001026317,0.000009322924,0.00004389558,0.00006724243,0.00001421747,0.0005234628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008160722,"threshold_uncertainty_score":0.002730072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04498953968632526,"score_gpt":0.2934881940812543,"score_spread":0.248498654394929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}