{"id":"W1975246455","doi":"10.2741/3034","title":"Antisense DNA and RNA agents against picornaviruses","year":2008,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Heart and Stroke Foundation of Canada","keywords":"Picornavirus; RNA; Deoxyribozyme; Nucleic acid; DNA; Oligonucleotide; Small interfering RNA; RNase H; Sense (electronics); Biology; Nuclease; Antisense RNA; Computational biology; Sense strand; Ribozyme; Curcumin; Gene; Chemistry; RNase P; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002260711,0.0006999015,0.0007079432,0.001191613,0.0002047996,0.0003292136,0.0004526564,0.0006871158,0.001705438],"category_scores_gemma":[0.0002252707,0.0001678064,0.0002019682,0.0007785867,0.0003062329,0.000577894,0.0002673217,0.0007206097,0.001566946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003296633,"about_ca_system_score_gemma":0.0003116083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003994899,"about_ca_topic_score_gemma":0.0006434672,"domain_scores_codex":[0.9998997,0.00001322583,0.000009120052,0.00001787707,0.00005118016,0.000008813581],"domain_scores_gemma":[0.9999483,0.00001926284,0.000009272783,0.000001907684,0.00001445851,0.000006793048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008505552,0.000122725,0.0001637438,0.007584767,0.00003731123,0.0005410533,0.00008647895,0.000526829,0.04767973,0.005444776,0.01212733,0.9256002],"study_design_scores_gemma":[0.00002946857,0.0002516407,0.0008621268,0.0008350363,0.00004056548,0.002676425,0.00004679999,0.0001349875,0.01078613,0.00168498,0.9826334,0.00001824429],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001261796,0.9931226,0.0009233392,0.0001964214,0.0003954878,0.00001833245,0.00001339827,0.00002518485,0.00404335],"genre_scores_gemma":[0.00430037,0.9899492,0.001084297,0.0002833112,0.000258262,0.00003109136,0.00003771629,0.000002642027,0.004053182],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001705438,"threshold_uncertainty_score":0.005705237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08998276517066123,"score_gpt":0.3824524205149582,"score_spread":0.292469655344297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}