{"id":"W1975246455","doi":"10.2741/3034","title":"Antisense DNA and RNA agents against picornaviruses","year":2008,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Heart and Stroke Foundation of Canada","keywords":"Picornavirus; RNA; Deoxyribozyme; Nucleic acid; DNA; Oligonucleotide; Small interfering RNA; RNase H; Sense (electronics); Biology; Nuclease; Antisense RNA; Computational biology; Sense strand; Ribozyme; Curcumin; Gene; Chemistry; RNase P; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001855124,0.0002524056,0.001023439,0.0007237078,0.0001863101,0.00003279572,0.0002114929,0.0002695284,0.00001008479],"category_scores_gemma":[0.0002049218,0.0001915056,0.0001527314,0.001028382,0.0009989933,0.0001246942,0.0001497399,0.0005691695,0.00003387428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001582859,"about_ca_system_score_gemma":0.0003255939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002257301,"about_ca_topic_score_gemma":0.000001368868,"domain_scores_codex":[0.9983706,0.0001093491,0.0003601269,0.0005112359,0.0002268155,0.000421878],"domain_scores_gemma":[0.9993277,0.00002864605,0.0001110042,0.0003697125,0.00003813006,0.0001248177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006435733,0.00008331497,0.001982952,0.0008393478,0.00003240306,0.0002067834,0.00002881481,3.299514e-8,0.00003484079,0.00000364099,0.01097551,0.9858059],"study_design_scores_gemma":[0.0002784684,0.0001464815,0.001090607,0.00362607,0.00004750199,0.0002920472,0.00002358191,0.00002803784,0.0000183826,0.000006322444,0.9942515,0.0001910305],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002394144,0.9941297,0.00006586778,0.0000352904,0.001211734,0.00055871,0.00001694354,0.00002980168,0.001557841],"genre_scores_gemma":[0.0001222488,0.997756,0.0008516571,0.000127696,0.00005707479,0.00002824245,0.00001369767,0.00002030429,0.001023053],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9856149,"threshold_uncertainty_score":0.780937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08998276517066123,"score_gpt":0.3824524205149582,"score_spread":0.292469655344297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}