{"id":"W1975266037","doi":"10.1128/jvi.03651-14","title":"Reduction of Virion-Associated σ1 Fibers on Oncolytic Reovirus Variants Promotes Adaptation toward Tumorigenic Cells","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Infectivity; Biology; Oncolytic virus; Virology; Capsid; Cell culture; Virus; Western blot; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001130658,0.0001336765,0.0002818044,0.0001707195,0.00003437159,0.000009362489,0.0002316102,0.0002198147,0.00002849796],"category_scores_gemma":[0.0003046288,0.0001196169,0.0001304208,0.0001500431,0.0001107191,0.0000102504,0.00003666219,0.0002453107,0.0000155307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000115285,"about_ca_system_score_gemma":0.0005510757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002096549,"about_ca_topic_score_gemma":0.00002752398,"domain_scores_codex":[0.9983374,0.0004064754,0.0004868154,0.0001888665,0.0003387674,0.0002416318],"domain_scores_gemma":[0.9986159,0.00003075758,0.00057919,0.0002095582,0.0004218025,0.000142814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006205838,0.0002779865,0.00006534799,0.000007277475,0.0001749702,0.00001764265,0.0003332346,0.002925369,0.9860001,0.000005766819,0.00137579,0.00261064],"study_design_scores_gemma":[0.002309854,0.02660684,0.0007494031,0.00002468429,0.00005516564,0.0001155279,0.0002389778,0.0004055754,0.9682297,0.0004351757,0.0006916525,0.0001374779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980716,0.0003896107,0.0002280421,0.0004499438,0.0005103988,0.0001569873,0.000008681138,0.000004117404,0.0001806102],"genre_scores_gemma":[0.9988446,0.0002163285,0.0003060678,0.00010679,0.0003042418,0.000003635664,0.00001320866,0.00002253599,0.000182551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02632885,"threshold_uncertainty_score":0.4877836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04440649276148088,"score_gpt":0.3129452167652581,"score_spread":0.2685387240037772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}