{"id":"W1975292133","doi":"10.1021/ml3001616","title":"Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes","year":2012,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research; U.S. Department of Energy","keywords":"Cyclooxygenase; Chemistry; Substrate (aquarium); Flurbiprofen; Selectivity; In vivo; Ibuprofen; Arachidonic acid; Potency; Endocannabinoid system; In vitro; Stereochemistry; Cannabinoid; Lead compound; Enzyme; Pharmacology; Biochemistry; Receptor; Medicine; Biology; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009964915,0.0001174781,0.0002293252,0.00005116884,0.00003664714,0.00000309363,0.00003933842,0.00007256903,0.00004951881],"category_scores_gemma":[0.0001229454,0.00009639718,0.00003270564,0.0001535129,0.0001977668,0.0000725362,0.00002707863,0.000192845,9.557326e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001373351,"about_ca_system_score_gemma":0.0002980363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002593391,"about_ca_topic_score_gemma":0.000001610228,"domain_scores_codex":[0.9983822,0.00003930818,0.000296492,0.0001547873,0.0008754355,0.0002517847],"domain_scores_gemma":[0.9992731,0.00001095694,0.0001304374,0.0001283926,0.0003069725,0.0001501308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001689999,0.0001474306,0.01769003,0.0007551698,0.0000635638,0.000003231411,0.001805168,0.000002236608,0.9734012,0.000005070975,0.001742042,0.004215881],"study_design_scores_gemma":[0.001201293,0.00005350296,0.1119526,0.0002002883,0.0001200877,0.00004639027,0.0007203248,0.00002069283,0.8853673,0.000006482409,0.0002351782,0.00007578243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956253,0.0006299132,0.000009312079,0.002444556,0.00002733304,0.0003959157,0.000003095289,0.000009322545,0.0008552605],"genre_scores_gemma":[0.9992946,0.000009218109,0.0001392809,0.0001303494,0.000167676,0.00006868951,0.00004676988,0.00001140216,0.0001319567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09426261,"threshold_uncertainty_score":0.3930963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02885931828693076,"score_gpt":0.305321653271301,"score_spread":0.2764623349843702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}