{"id":"W1975292133","doi":"10.1021/ml3001616","title":"Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes","year":2012,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research; U.S. Department of Energy","keywords":"Cyclooxygenase; Chemistry; Substrate (aquarium); Flurbiprofen; Selectivity; In vivo; Ibuprofen; Arachidonic acid; Potency; Endocannabinoid system; In vitro; Stereochemistry; Cannabinoid; Lead compound; Enzyme; Pharmacology; Biochemistry; Receptor; Medicine; Biology; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003052974,0.0004299541,0.0002378155,0.0002045974,0.0001245195,0.000229727,0.0003036984,0.0002791449,0.0009889388],"category_scores_gemma":[0.0002852328,0.0001248845,0.0001932837,0.0001588222,0.0001879515,0.0003850526,0.0002234541,0.0004804318,0.0002411691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002046491,"about_ca_system_score_gemma":0.0001304434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002932011,"about_ca_topic_score_gemma":0.000745739,"domain_scores_codex":[0.9998511,0.00003890382,0.00001163483,0.00002609837,0.00003603499,0.00003618058],"domain_scores_gemma":[0.9998707,0.00002590976,0.00003562204,0.00001471697,0.00002545492,0.00002755839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002599707,0.00008813625,0.0002339113,0.0001174672,0.00001348184,0.0001467632,0.00005619511,0.0007427435,0.9833624,0.0007580822,0.00008973583,0.0141311],"study_design_scores_gemma":[0.00003622558,0.001338388,0.0005114336,0.000007339717,0.00001847053,0.0002830623,0.00002392878,0.000806584,0.9932235,0.00009174547,0.003647835,0.00001138191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746971,0.005834734,0.01340316,0.0001466216,0.00003639301,0.0001867035,0.0003834208,0.00007202079,0.005239797],"genre_scores_gemma":[0.9837272,0.004524985,0.00910541,0.00008193035,0.00001773158,0.0000703097,0.0003980234,0.00001390623,0.002060581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009889388,"threshold_uncertainty_score":0.003308296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02885931828693076,"score_gpt":0.305321653271301,"score_spread":0.2764623349843702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}