{"id":"W1975294927","doi":"10.1242/jcs.094029","title":"Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells","year":2012,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Biology; RANKL; RANK Ligand; Cell biology; Cell growth; Osteosarcoma; Motility; Paracrine signalling; Signal transduction; Autocrine signalling; Cancer research; Receptor; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008148585,0.00009362027,0.0001443081,0.00007050906,0.00008485772,0.00006877478,0.0001608763,0.00004788237,0.000004266859],"category_scores_gemma":[0.00004646823,0.00007391896,0.00003559415,0.00009984093,0.0001936457,0.0000400346,0.0001026792,0.00007268476,4.033009e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004966129,"about_ca_system_score_gemma":0.0001130291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003545194,"about_ca_topic_score_gemma":0.000003135997,"domain_scores_codex":[0.9990946,0.00008202765,0.0002438573,0.0001519886,0.0002077286,0.0002197846],"domain_scores_gemma":[0.9994386,0.00001831383,0.0001398558,0.0001159777,0.00009047892,0.0001967356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005613754,0.0001033436,0.04154725,0.00002107161,0.000002054616,0.000001945912,0.00009577392,0.00001029268,0.9574581,0.00001394251,0.00001023221,0.0006798111],"study_design_scores_gemma":[0.0005376189,0.00007582621,0.1910881,0.000005908307,0.00001543246,0.00001323309,0.00004000871,0.00004709993,0.8078846,0.0001237569,0.00009935173,0.00006914363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949376,0.004095959,0.0005103879,0.00003840871,0.0002288314,0.00006975036,0.000004151158,0.000001477892,0.0001134629],"genre_scores_gemma":[0.9984001,0.0002740782,0.001041045,0.00003358848,0.0001902216,6.482814e-7,0.000001032544,0.000004399416,0.00005486731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1495736,"threshold_uncertainty_score":0.3014328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006384199644249305,"score_gpt":0.21528190992254,"score_spread":0.2088977102782907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}