{"id":"W1975294927","doi":"10.1242/jcs.094029","title":"Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells","year":2012,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Biology; RANKL; RANK Ligand; Cell biology; Cell growth; Osteosarcoma; Motility; Paracrine signalling; Signal transduction; Autocrine signalling; Cancer research; Receptor; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008108972,0.0002020664,0.0002306063,0.0002975857,0.0001313965,0.0002148865,0.0000660672,0.0001470924,0.001133558],"category_scores_gemma":[0.00005012632,0.00009275239,0.0001815662,0.0002119561,0.0001445537,0.0001117943,0.0001237173,0.0002369258,0.0003114324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001670486,"about_ca_system_score_gemma":0.0001873712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001153901,"about_ca_topic_score_gemma":0.002061051,"domain_scores_codex":[0.9998623,0.00001490759,0.00001223662,0.00002161801,0.0000416254,0.00004721172],"domain_scores_gemma":[0.9999499,0.000005930586,0.0000116441,0.000005973054,0.00000722293,0.00001922338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009834608,0.00002418704,0.0003681686,0.00002199,0.000002185414,0.00004603629,0.00001446743,0.00003335505,0.9983873,0.00008205807,0.00002702086,0.0008949719],"study_design_scores_gemma":[0.00002055785,0.0005579333,0.03159964,0.000005305193,0.00002178353,0.000560332,0.0001352702,0.0008917479,0.9628463,0.00007531435,0.003277353,0.000008507681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962735,0.001587887,0.0006362296,0.0000412163,0.00001003248,0.00001288518,0.0002911175,0.00002432142,0.001122921],"genre_scores_gemma":[0.9950833,0.0009957111,0.0005225401,0.00003206504,0.000005934876,0.00001872786,0.0005358433,0.000006430131,0.002799555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153901,"threshold_uncertainty_score":0.003792167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006384199644249305,"score_gpt":0.21528190992254,"score_spread":0.2088977102782907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}