{"id":"W1975382383","doi":"10.1158/1538-7445.am10-1576","title":"Abstract 1576: Molecular targeting of histone deacetylase 2 for treatment of human hepatocellular carcinoma","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Histone deacetylase 2; Gene silencing; Cancer research; Biology; Histone deacetylase; Cell growth; Molecular biology; Cell culture; Gene expression; Small interfering RNA; Chemistry; Histone; Transfection; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196367,0.0004625839,0.0005268498,0.0003157354,0.0001110866,0.0001842613,0.0002307902,0.0003143816,0.003376675],"category_scores_gemma":[0.00005803761,0.0001101096,0.0003094368,0.0002691854,0.0001011523,0.000139221,0.0001822362,0.0004837278,0.00151751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002561661,"about_ca_system_score_gemma":0.0002737718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003978029,"about_ca_topic_score_gemma":0.0006288952,"domain_scores_codex":[0.9999145,0.00001322913,0.000008713356,0.00001495198,0.00003355221,0.00001507994],"domain_scores_gemma":[0.9999772,0.000001616254,0.000004751344,0.000002531502,0.000006996544,0.000006764257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003292859,0.0000997633,0.0001734338,0.0003004525,0.00003102284,0.0000835654,0.00001024879,0.0001120077,0.9852706,0.0001412835,0.001155496,0.01229275],"study_design_scores_gemma":[0.0002272003,0.001475077,0.002651413,0.00002240847,0.00008029529,0.0005089864,0.00001263159,0.0006819559,0.9682915,0.00006577022,0.02597126,0.00001158219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8537663,0.08879936,0.02518442,0.00167834,0.001762913,0.000762672,0.004353742,0.001146074,0.02254617],"genre_scores_gemma":[0.9225988,0.02572001,0.01478591,0.0007600012,0.0002827112,0.0004954927,0.00657066,0.0001116928,0.0286746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003376675,"threshold_uncertainty_score":0.01129603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04699315977972056,"score_gpt":0.4171567364785402,"score_spread":0.3701635766988196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}