{"id":"W1975432631","doi":"10.1002/pro.290","title":"Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIβ binding protein 1","year":2009,"lang":"en","type":"article","venue":"Protein Science","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; National Institutes of Health; Canadian Light Source; Howard Hughes Medical Institute","keywords":"Binding site; Biology; Poly ADP ribose polymerase; Binding domain; Polymerase; HMG-box; Protein structure; Biophysics; Transcription factor; Cell biology; DNA; Biochemistry; Molecular biology; Chemistry; DNA-binding protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003102991,0.000534269,0.000698448,0.0001833683,0.0005146685,0.0009435927,0.0007188164,0.0005684461,0.001972567],"category_scores_gemma":[0.0004545832,0.0003722613,0.0002976277,0.0002678621,0.0002469266,0.0005753068,0.000378227,0.002041113,0.0005224808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008025335,"about_ca_system_score_gemma":0.0008473466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003018503,"about_ca_topic_score_gemma":0.005258185,"domain_scores_codex":[0.9998833,0.00001569622,0.00000601089,0.00001406576,0.0000585916,0.00002230705],"domain_scores_gemma":[0.9998887,0.00002558027,0.00002237265,0.000005825213,0.00002189013,0.00003563563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00215739,0.0008387017,0.01282141,0.002376043,0.0003208656,0.004576912,0.001093859,0.04137556,0.8283367,0.01460051,0.0341078,0.05739428],"study_design_scores_gemma":[0.002789994,0.001824476,0.07962438,0.0008293989,0.001050287,0.007383308,0.003306341,0.2863938,0.2937485,0.01864832,0.303999,0.0004022451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9466252,0.02241462,0.009905665,0.00358823,0.0005558676,0.00008384345,0.003084276,0.0005729928,0.01316927],"genre_scores_gemma":[0.9438754,0.01837281,0.01951304,0.001061798,0.0001435646,0.00006464162,0.01143085,0.0001072745,0.005430648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003018503,"threshold_uncertainty_score":0.00659883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007548259775619166,"score_gpt":0.2340927146410415,"score_spread":0.2265444548654223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}