{"id":"W1975432631","doi":"10.1002/pro.290","title":"Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIβ binding protein 1","year":2009,"lang":"en","type":"article","venue":"Protein Science","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; National Institutes of Health; Canadian Light Source; Howard Hughes Medical Institute","keywords":"Binding site; Biology; Poly ADP ribose polymerase; Binding domain; Polymerase; HMG-box; Protein structure; Biophysics; Transcription factor; Cell biology; DNA; Biochemistry; Molecular biology; Chemistry; DNA-binding protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349057,0.0001030099,0.0001028482,0.00002375037,0.000176164,0.00002540934,0.0006926449,0.00005752183,0.00001153618],"category_scores_gemma":[0.00004853174,0.00005683359,0.00006327572,0.000311152,0.000348366,0.000007535882,0.0001340042,0.00008633299,3.084505e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001554351,"about_ca_system_score_gemma":0.0001999345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006076866,"about_ca_topic_score_gemma":0.00005020892,"domain_scores_codex":[0.9990302,0.00004570637,0.0001716043,0.0002628674,0.0003246194,0.0001649736],"domain_scores_gemma":[0.9992157,0.000005398021,0.0001578906,0.0004957777,0.00008605502,0.0000391836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000030553,0.00001847228,0.00002410585,0.000003643252,0.000005941707,1.882298e-7,0.0001617641,0.000006927681,0.9949806,0.003239019,0.000004054507,0.001524722],"study_design_scores_gemma":[0.0002146717,0.0001813319,0.0006029229,0.00004011326,0.000004758967,0.000001142451,0.0001000955,0.00001141726,0.9855939,0.01202158,0.001147688,0.00008040976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979352,0.0003271938,0.0005320494,0.0003612315,0.00007366795,0.0005922791,0.00004490171,0.000003139502,0.0001303812],"genre_scores_gemma":[0.9984505,0.00000473737,0.001229773,0.0001532105,0.00006631153,0.00000943918,0.000003460633,0.000005190477,0.00007741294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009386735,"threshold_uncertainty_score":0.2317606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007548259775619166,"score_gpt":0.2340927146410415,"score_spread":0.2265444548654223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}