{"id":"W1975456474","doi":"10.1128/aac.04046-14","title":"Effect of Steady-State Faldaprevir on the Pharmacokinetics of Steady-State Methadone and Buprenorphine-Naloxone in Subjects Receiving Stable Addiction Management Therapy","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Buprenorphine; (+)-Naloxone; Methadone; Pharmacokinetics; Medicine; Dosing; Opioid; Anesthesia; Pharmacodynamics; Pharmacology; Narcotic antagonist; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007145546,0.0002169034,0.0004430881,0.0001889116,0.0002095532,0.0005002217,0.0001092888,0.0002988692,0.0008796368],"category_scores_gemma":[0.002288184,0.0002018981,0.0002567099,0.000154171,0.0002145771,0.0002737532,0.0001675625,0.000331884,0.0001569898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002769328,"about_ca_system_score_gemma":0.0002159925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009263,"about_ca_topic_score_gemma":0.001149563,"domain_scores_codex":[0.9996113,0.000190699,0.00002594828,0.00004894535,0.00006848188,0.00005452395],"domain_scores_gemma":[0.9991363,0.0003394692,0.0001992847,0.00005620628,0.00009725217,0.0001715159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1070185,0.006285842,0.4915189,0.0001800626,0.0008581046,0.0009022323,0.001204249,0.001663796,0.2100467,0.0001926408,0.0004898445,0.1796391],"study_design_scores_gemma":[0.000716544,0.08645467,0.8827924,0.00001811081,0.000384304,0.0008458789,0.000279012,0.003810136,0.02363983,0.00008148998,0.0009416714,0.00003600411],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995733,0.0001634931,0.00007418695,0.00001042576,0.000002625096,0.000008651999,0.0000185362,0.000008429583,0.0001404061],"genre_scores_gemma":[0.9996021,0.00006466132,0.0001248594,0.00002424573,0.000004924264,0.000007617371,0.00005837069,0.000002357943,0.0001108649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009263,"threshold_uncertainty_score":0.003778994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108524413761043,"score_gpt":0.2604070269074129,"score_spread":0.2495545855313085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}