{"id":"W1975478809","doi":"10.1074/jbc.m313543200","title":"A Polymorphic Autoregulatory Hormone Response Element in the Human Estrogen-related Receptor α (ERRα) Promoter Dictates Peroxisome Proliferator-activated Receptor γ Coactivator-1α Control of ERRα Expression","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-François d'Assise; Alethia Biotherapeutics (Canada); McGill University","funders":"","keywords":"Coactivator; Peroxisome proliferator-activated receptor; Nuclear receptor; Receptor; Response element; Hormone response element; Estrogen-related receptor alpha; PELP-1; Estrogen-related receptor gamma; Nuclear receptor coactivator 3; Estrogen receptor; Cell biology; Biology; Endocrinology; Transcription factor; Promoter; Biochemistry; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001269319,0.0003877734,0.0005631655,0.00007105427,0.000126984,0.00002866968,0.0005556282,0.0007939932,0.00005876373],"category_scores_gemma":[0.000356509,0.0002329713,0.0003549927,0.0002311225,0.000339416,0.0000196558,0.00009375717,0.0007942232,0.000003419222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001261114,"about_ca_system_score_gemma":0.000244935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003924906,"about_ca_topic_score_gemma":7.744916e-8,"domain_scores_codex":[0.9971931,0.00053189,0.001037191,0.0003966977,0.0003946122,0.0004465177],"domain_scores_gemma":[0.9982674,0.00009195336,0.0008626344,0.0003876142,0.0001860764,0.000204363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004180668,0.0007903688,0.002441266,0.00002638605,0.0002148029,0.00004063942,0.0001607709,0.00006917975,0.9917623,0.0000234825,0.0002278829,0.00006221402],"study_design_scores_gemma":[0.00460082,0.002379138,0.003518895,0.0001612274,0.00003849594,0.0001726939,0.0002548885,0.000004193857,0.9877292,0.0001047,0.0007562758,0.0002794512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941003,0.004891979,0.00003363989,0.0003917385,0.00007540993,0.0004165614,0.00003382178,0.00001662992,0.00003987725],"genre_scores_gemma":[0.9990705,0.0002398308,0.0002135109,0.00009173567,0.0002145637,0.00003391993,0.00007342751,0.00003068471,0.00003182418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00497016,"threshold_uncertainty_score":0.9500293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009344488368934149,"score_gpt":0.2404461242494725,"score_spread":0.2311016358805383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}