{"id":"W1975478809","doi":"10.1074/jbc.m313543200","title":"A Polymorphic Autoregulatory Hormone Response Element in the Human Estrogen-related Receptor α (ERRα) Promoter Dictates Peroxisome Proliferator-activated Receptor γ Coactivator-1α Control of ERRα Expression","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-François d'Assise; Alethia Biotherapeutics (Canada); McGill University","funders":"","keywords":"Coactivator; Peroxisome proliferator-activated receptor; Nuclear receptor; Receptor; Response element; Hormone response element; Estrogen-related receptor alpha; PELP-1; Estrogen-related receptor gamma; Nuclear receptor coactivator 3; Estrogen receptor; Cell biology; Biology; Endocrinology; Transcription factor; Promoter; Biochemistry; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002169597,0.0004464996,0.0003527899,0.0002477723,0.0001635048,0.0002535484,0.0003318248,0.0003219239,0.001663528],"category_scores_gemma":[0.0003360227,0.0003402353,0.0005324587,0.0001935368,0.0003521145,0.0001338076,0.000273616,0.0007597774,0.001537355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000271508,"about_ca_system_score_gemma":0.0003440104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003240226,"about_ca_topic_score_gemma":0.0007242968,"domain_scores_codex":[0.999761,0.00004931601,0.0000158408,0.00008386928,0.00005821318,0.00003179032],"domain_scores_gemma":[0.9997335,0.00007747326,0.00007359075,0.0000378855,0.00002224054,0.00005524717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001188494,0.00002283834,0.0003322435,0.00001953558,0.000004288923,0.0001145379,0.0000176075,0.0000826607,0.9976103,0.0001442536,0.00003475733,0.00149819],"study_design_scores_gemma":[0.00004719921,0.0003799828,0.01101842,0.00002433415,0.00002733941,0.00127334,0.00005985387,0.002027569,0.9793319,0.0001636226,0.005623984,0.00002251086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664233,0.001464828,0.0289344,0.0001838449,0.0001130602,0.000101264,0.0009625576,0.0004939187,0.001322953],"genre_scores_gemma":[0.9677367,0.0007289837,0.02581416,0.0001378725,0.00003015744,0.0001130235,0.00196065,0.0001570441,0.003321427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001663528,"threshold_uncertainty_score":0.005565107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009344488368934149,"score_gpt":0.2404461242494725,"score_spread":0.2311016358805383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}