{"id":"W1975488070","doi":"10.1021/ac050150y","title":"Discovery, Biosynthesis, and Structure Elucidation of Metabolites of a Doping Agent and a Direct Analogue, Tetrahydrogestrinone and Gestrinone, Using Human Hepatocytes","year":2005,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Metabolite; In vitro; In vivo; Metabolic pathway; Urinary system; Biochemistry; Glucuronide; Oxidative phosphorylation; Metabolism; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008558661,0.000143583,0.0004754151,0.00004591115,0.00005431185,0.0000110232,0.00002683773,0.00006941587,0.000008168759],"category_scores_gemma":[0.0001445939,0.0001064841,0.00004927957,0.0001218793,0.0003980134,0.0000780042,0.00007263296,0.00009909928,4.731179e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001692646,"about_ca_system_score_gemma":0.00002355842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008845821,"about_ca_topic_score_gemma":0.000005058478,"domain_scores_codex":[0.9991345,0.00001239334,0.0002708562,0.0002948736,0.0001539996,0.0001333397],"domain_scores_gemma":[0.9995456,0.00007086506,0.00009800914,0.0001375405,0.00006850879,0.00007948984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004604908,0.00006918847,0.1586223,0.0004834168,0.0002848695,0.000004802657,0.00007749861,0.000002970941,0.8390095,0.0001051016,0.000003442462,0.001290912],"study_design_scores_gemma":[0.0003808351,0.00004219497,0.1685163,0.000142226,0.0004941695,0.00004803785,0.0001524985,0.000514773,0.8294833,0.00005917972,0.00005818859,0.000108236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923623,0.006844111,0.00001068104,0.0001650546,0.000003286991,0.0000845923,0.00003902246,0.000007830409,0.0004830944],"genre_scores_gemma":[0.9986796,0.0006949611,0.0004184425,0.000008462125,0.000107443,0.000001008245,0.00001331682,0.000007753621,0.00006898625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009894069,"threshold_uncertainty_score":0.4342296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02092100673893216,"score_gpt":0.2837437953841851,"score_spread":0.2628227886452529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}