{"id":"W1975488070","doi":"10.1021/ac050150y","title":"Discovery, Biosynthesis, and Structure Elucidation of Metabolites of a Doping Agent and a Direct Analogue, Tetrahydrogestrinone and Gestrinone, Using Human Hepatocytes","year":2005,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Metabolite; In vitro; In vivo; Metabolic pathway; Urinary system; Biochemistry; Glucuronide; Oxidative phosphorylation; Metabolism; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040044,0.0002802967,0.0001238404,0.0001703871,0.0001173913,0.0002106001,0.00008145864,0.0002169886,0.0004511779],"category_scores_gemma":[0.0001449682,0.0001070933,0.000221298,0.0001517385,0.0001505005,0.0001616268,0.0001464853,0.0001706346,0.0002874641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001425944,"about_ca_system_score_gemma":0.0002710975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007181886,"about_ca_topic_score_gemma":0.001024147,"domain_scores_codex":[0.99993,0.00001788844,0.00000574913,0.00002139496,0.00001532805,0.000009618794],"domain_scores_gemma":[0.9999229,0.00001241069,0.00001909857,0.00001415838,0.00001879702,0.00001265916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001010963,0.00001312324,0.0003745157,0.00002488002,0.00000629895,0.00007152777,0.00001333457,0.00005912163,0.9960279,0.00003672364,0.00001461564,0.0032569],"study_design_scores_gemma":[0.000005120566,0.0001787665,0.001809477,0.000001253734,0.00001274226,0.0001058105,0.00001083819,0.0001263184,0.9967911,0.00001561937,0.0009406108,0.00000243009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754219,0.00418388,0.01589445,0.0001514346,0.00003673409,0.000077505,0.001026378,0.0001062692,0.003101459],"genre_scores_gemma":[0.9803352,0.002650647,0.01271096,0.00006130464,0.00001711504,0.00003802083,0.001128773,0.00002384328,0.003034119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007181886,"threshold_uncertainty_score":0.001509368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02092100673893216,"score_gpt":0.2837437953841851,"score_spread":0.2628227886452529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}