{"id":"W1975491952","doi":"10.1093/cvr/cvt336","title":"Elastin-derived peptides potentiate atherosclerosis through the immune Neu1–PI3Kγ pathway","year":2013,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Fondation de France; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Canadian Diabetes Association","keywords":"Elastin; PI3K/AKT/mTOR pathway; Cathepsin G; Neuraminidase; Chemistry; In vivo; Cell biology; Cathepsin D; In vitro; Biology; Signal transduction; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001344298,0.0005667833,0.0002856309,0.0002615636,0.0001271167,0.000230961,0.0001605596,0.0002814823,0.001889643],"category_scores_gemma":[0.0001112506,0.0001316811,0.000327983,0.0001138163,0.000195488,0.0002098969,0.0002745018,0.0009371217,0.0003544016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001675636,"about_ca_system_score_gemma":0.0001724071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002076862,"about_ca_topic_score_gemma":0.00037789,"domain_scores_codex":[0.9998854,0.00002122361,0.00001049408,0.00001652819,0.00002673035,0.00003957012],"domain_scores_gemma":[0.9999392,0.000005687315,0.00002033736,0.000007553707,0.000007335603,0.00001982962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001291898,0.00022075,0.0002811395,0.0001396848,0.0000160831,0.0001233706,0.00001874458,0.00008224466,0.9928553,0.0001311419,0.00009597364,0.004743728],"study_design_scores_gemma":[0.0002123576,0.00328037,0.01581609,0.0000485795,0.000101688,0.0004966554,0.00005955907,0.001204522,0.9732721,0.0002642629,0.005233529,0.00001028456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907901,0.00402999,0.001614859,0.0002358076,0.00007410447,0.00005335296,0.0002522364,0.0001085147,0.002841081],"genre_scores_gemma":[0.9918309,0.00261349,0.001284269,0.0001165054,0.00003152592,0.00008307042,0.0003046128,0.00001474417,0.003720924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001889643,"threshold_uncertainty_score":0.00632149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05402886693900592,"score_gpt":0.3060518249661093,"score_spread":0.2520229580271034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}