{"id":"W1975501206","doi":"10.1128/aac.02459-12","title":"Antibiotic Trapping by Plasmid-Encoded CMY-2 β-Lactamase Combined with Reduced Outer Membrane Permeability as a Mechanism of Carbapenem Resistance in Escherichia coli","year":2013,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary","funders":"","keywords":"Meropenem; Porin; Microbiology; Escherichia coli; Bacterial outer membrane; Carbapenem; Plasmid; Membrane permeability; Biology; Chemistry; Antibiotic resistance; Antibiotics; Biochemistry; Gene; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009417274,0.0002881833,0.0003232013,0.0001378551,0.00009352875,0.0003878041,0.0001600118,0.0003620966,0.0003348843],"category_scores_gemma":[0.0002139542,0.0001381496,0.0002588656,0.0001286888,0.0002271445,0.0001920877,0.000241749,0.0003800776,0.0001490055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001718017,"about_ca_system_score_gemma":0.00008410769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000329719,"about_ca_topic_score_gemma":0.0001797628,"domain_scores_codex":[0.9998682,0.00003050015,0.0000140407,0.00002863913,0.00002514328,0.00003348764],"domain_scores_gemma":[0.9999137,0.00001581529,0.00003310075,0.00001313226,0.000007678291,0.00001660979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001549731,0.00006954158,0.002047385,0.00002760849,0.000008433239,0.000932597,0.00002435602,0.00006596458,0.9953036,0.00004858805,0.00001835821,0.001298629],"study_design_scores_gemma":[0.00004706428,0.001534646,0.02597831,0.00001162126,0.00004902389,0.01087304,0.0001275059,0.003085243,0.9567204,0.00008729632,0.001466932,0.00001880907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984254,0.0003882947,0.0009377024,0.00006461027,0.000007722058,0.000009516119,0.00001977256,0.0000222459,0.0001247371],"genre_scores_gemma":[0.9985743,0.0001907811,0.000878847,0.0000269288,0.000005432687,0.000006695633,0.00005829949,0.000005823184,0.0002528594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003878041,"threshold_uncertainty_score":0.001246452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00581513683006156,"score_gpt":0.2148793619786376,"score_spread":0.209064225148576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}