{"id":"W1975507912","doi":"10.1073/pnas.1011651107","title":"M <sub>3</sub> -muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Wellcome Trust; U.S. Department of Health and Human Services","keywords":"Interleukin-13 receptor; Muscarinic acetylcholine receptor M5; Muscarinic acetylcholine receptor M3; Cell biology; Phosphorylation; Enzyme-linked receptor; G protein-coupled receptor kinase; Arrestin; Biology; G protein-coupled receptor; Insulin receptor; 5-HT5A receptor; Chemistry; Receptor; Endocrinology; Muscarinic acetylcholine receptor; Signal transduction; Insulin-like growth factor 1 receptor; Biochemistry; Insulin; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151074,0.0003166968,0.0002253194,0.0001259817,0.00008762683,0.0002251818,0.0001683014,0.0001748808,0.001191574],"category_scores_gemma":[0.00007087658,0.0001012382,0.0003197649,0.00008807923,0.0001664259,0.0001719026,0.00016724,0.0006486765,0.0005857498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000264642,"about_ca_system_score_gemma":0.0001569463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00040887,"about_ca_topic_score_gemma":0.0009799318,"domain_scores_codex":[0.9998901,0.0000136449,0.00001383963,0.00001704786,0.00002661192,0.00003877731],"domain_scores_gemma":[0.9999371,0.000006494751,0.00003074275,0.0000060421,0.000006189036,0.00001350117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001577851,0.00001508299,0.0002037209,0.00003456352,0.000007053421,0.00006007301,0.000005859376,0.00003143873,0.9987752,0.0001217546,0.00006687659,0.0005206328],"study_design_scores_gemma":[0.00002986968,0.0002524497,0.007857798,0.00001037313,0.00002788513,0.0003237094,0.00003092056,0.0007204599,0.9872327,0.00006187594,0.003447963,0.000003951122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906766,0.002282614,0.0032637,0.0002939462,0.00007577684,0.00003038516,0.0005886462,0.0001365641,0.002651647],"genre_scores_gemma":[0.9906501,0.001655059,0.003318406,0.0001977469,0.00003186211,0.00006531057,0.0006617052,0.00004286547,0.003376886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191574,"threshold_uncertainty_score":0.003986239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525328129142174,"score_gpt":0.2504899511059185,"score_spread":0.2352366698144967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}