{"id":"W1975526402","doi":"10.1016/j.suc.2008.04.006","title":"Hereditary Diffuse Gastric Cancer: Prophylactic Surgical Oncology Implications","year":2008,"lang":"en","type":"review","venue":"Surgical Clinics of North America","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of British Columbia; Memorial University of Newfoundland","funders":"National Cancer Institute","keywords":"Medicine; CDH1; Prophylactic Surgery; Penetrance; Cancer; Cancer syndrome; Gastrectomy; Germline mutation; Oncology; Internal medicine; Surgery; Mutation; Gene; Cadherin; Genetics; Breast cancer; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001593664,0.0006097163,0.002073484,0.0001448183,0.000137669,0.00001222857,0.0008024024,0.000656902,0.0001532351],"category_scores_gemma":[0.00009510219,0.0005021891,0.001098324,0.0007110586,0.0006187991,0.000005799732,0.0003455405,0.0006709811,0.00005821167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00010891,"about_ca_system_score_gemma":0.002376444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003690547,"about_ca_topic_score_gemma":0.00001602038,"domain_scores_codex":[0.9962409,0.0003485845,0.00152352,0.0009628395,0.0003357358,0.0005883781],"domain_scores_gemma":[0.9970777,0.0003816119,0.001179646,0.0007612109,0.0002779714,0.0003218388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001120534,0.000443905,0.0006253511,0.0008498856,0.0003491835,0.0001575469,0.000007678887,0.00001619525,6.395555e-7,0.000002290798,0.004071893,0.9933634],"study_design_scores_gemma":[0.0006593755,0.0006058094,0.00008327526,0.0002843667,0.00032823,0.0004548378,0.000003037582,0.000001629652,0.000002439444,0.000004430384,0.9970338,0.0005387419],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001404245,0.9955608,0.00003084178,0.0000737568,0.0005459017,0.0006330458,0.0003904597,0.00003290625,0.001328087],"genre_scores_gemma":[0.0006438943,0.9944072,0.0004584246,0.00006594515,0.001210016,0.000457475,0.00196792,0.00009116743,0.0006979698],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9929619,"threshold_uncertainty_score":0.999743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04160765482922825,"score_gpt":0.3609995645728159,"score_spread":0.3193919097435877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}