{"id":"W1975545676","doi":"10.1093/oxfordjournals.jbchem.a002944","title":"Caspase-Independent Cell Death and Mitochondrial Disruptions Observed in the Apaf1-Deficient Cells","year":2001,"lang":"en","type":"article","venue":"The Journal of Biochemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Programmed cell death; Apoptosis; Cell biology; Mitochondrion; Caspase; Necrosis; Biology; Mitochondrial apoptosis-induced channel; Molecular biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001131976,0.0004146122,0.0002994059,0.0002400887,0.0001940168,0.0003593656,0.0002406059,0.000395457,0.001222163],"category_scores_gemma":[0.0001875222,0.0001444085,0.0002391164,0.0002028977,0.0002467419,0.0002910935,0.0001890857,0.0009126964,0.0006880692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002472562,"about_ca_system_score_gemma":0.0001406764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002833677,"about_ca_topic_score_gemma":0.0002339252,"domain_scores_codex":[0.9998054,0.00002251776,0.00002653549,0.00004049043,0.00007293012,0.00003210981],"domain_scores_gemma":[0.9997594,0.00004808668,0.00005726365,0.00005154748,0.00003153009,0.0000522218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005270958,0.00001209597,0.0001034268,0.00001850886,0.000003440428,0.0001132228,0.00001286856,0.0000273043,0.9990682,0.00008306754,0.00001635652,0.0004887123],"study_design_scores_gemma":[0.00001058748,0.0001006504,0.002743451,0.000002933348,0.00000800712,0.0008608141,0.00002165695,0.0003374591,0.9948545,0.00006324625,0.0009932033,0.000003510905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904399,0.001517412,0.005322826,0.0001083262,0.00003948513,0.00002975144,0.0009538233,0.0001141861,0.001474387],"genre_scores_gemma":[0.9933577,0.0006669803,0.002169585,0.00003577011,0.0000067716,0.00003452335,0.001134183,0.0000197243,0.002574747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222163,"threshold_uncertainty_score":0.004088521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01537374140305198,"score_gpt":0.2365198637377219,"score_spread":0.22114612233467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}