{"id":"W1975582440","doi":"10.1016/j.neuroscience.2011.12.030","title":"Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis","year":2011,"lang":"en","type":"review","venue":"Neuroscience","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":338,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"National Institute of Mental Health","keywords":"Endocannabinoid system; Neuroscience; Cannabinoid receptor; Glucocorticoid; Anandamide; Internal medicine; Endocrinology; 2-Arachidonoylglycerol; Negative feedback; Biology; Medicine; Receptor; Antagonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004236079,0.0009243231,0.001284342,0.001351418,0.0003172483,0.0009966185,0.0009215302,0.001002223,0.002758344],"category_scores_gemma":[0.0004010579,0.0002477532,0.0002836342,0.001988691,0.00063964,0.001026946,0.0006456908,0.001335793,0.001444227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000948723,"about_ca_system_score_gemma":0.001609238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002828445,"about_ca_topic_score_gemma":0.006691003,"domain_scores_codex":[0.9998789,0.00001454462,0.00001552007,0.00002368659,0.00005114708,0.00001628514],"domain_scores_gemma":[0.9998592,0.00005019664,0.00002384655,0.000004427018,0.00004160725,0.00002067874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000225657,0.00009091511,0.0003071913,0.01121997,0.0001089109,0.0004440674,0.00005033423,0.0005610624,0.007339981,0.004648989,0.02234795,0.9526552],"study_design_scores_gemma":[0.00003870318,0.00008987841,0.002938181,0.002248283,0.0001524216,0.001946959,0.000137063,0.0002053158,0.00165504,0.004463865,0.9860854,0.00003892134],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001601471,0.9986696,0.0001158672,0.0001735953,0.0001115212,0.000002811909,0.00001500726,0.00000408134,0.0007473791],"genre_scores_gemma":[0.0008319036,0.9983045,0.0001330431,0.0000786939,0.0001175413,0.000002980093,0.00002290529,5.992948e-7,0.0005078593],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002828445,"threshold_uncertainty_score":0.009227633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04734807469079311,"score_gpt":0.3098380159169338,"score_spread":0.2624899412261407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}