{"id":"W1975697730","doi":"10.1016/j.addr.2011.01.004","title":"Lessons from (patho)physiological tissue stiffness and their implications for drug screening, drug delivery and regenerative medicine","year":2011,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Regenerative medicine; Regeneration (biology); Tissue engineering; Extracellular matrix; Function (biology); Drug delivery; Neuroscience; Cell function; Cell biology; Cell; Biology; Stem cell; Medicine; Chemistry; Biomedical engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000419114,0.000789949,0.001960639,0.00009450362,0.0003542234,0.00003615757,0.0004244864,0.0002655905,0.00004427558],"category_scores_gemma":[0.0001710861,0.0005471308,0.0004310498,0.0001486647,0.0001958265,0.00002782289,0.0003946903,0.0003526856,0.00001101315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003436151,"about_ca_system_score_gemma":0.00009491098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001150147,"about_ca_topic_score_gemma":0.0002521315,"domain_scores_codex":[0.9968264,0.0003898499,0.0009554513,0.001330248,0.00006017246,0.0004378938],"domain_scores_gemma":[0.9976283,0.0002082265,0.0007496341,0.00092119,0.0002310123,0.0002616603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002337882,0.00004960213,4.267447e-7,0.0008606198,0.0001573657,7.271277e-7,0.0001202765,4.101887e-7,0.01689905,0.0003366904,0.00859755,0.9729539],"study_design_scores_gemma":[0.0003662923,0.00008967023,0.000006384406,0.003265309,0.0005585528,0.00002194418,0.00009365451,0.00001555817,0.0009029931,0.0005973425,0.9934809,0.0006013873],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001104848,0.9907713,0.004235403,0.0002042716,0.0002896497,0.002172109,0.001123847,0.00002443319,0.00007417317],"genre_scores_gemma":[0.0002278256,0.9891989,0.003336873,0.0002660493,0.0005349163,0.001061307,0.004197286,0.00008741501,0.001089379],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9848834,"threshold_uncertainty_score":0.999698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0804056353883073,"score_gpt":0.3530512046880852,"score_spread":0.2726455692997778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}