{"id":"W1975703199","doi":"10.1038/mt.sj.6300122","title":"Engineered Human tmpk/AZT As a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy","year":2007,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Terry Fox Foundation","keywords":"Suicide gene; Jurkat cells; Prodrug; Genetic enhancement; Viral vector; Cancer research; Cytotoxic T cell; Transplantation; Biology; Cell culture; Chemistry; Molecular biology; Pharmacology; Biochemistry; Gene; T cell; Medicine; Immunology; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001221007,0.0005114517,0.0003706541,0.0002106765,0.0002478629,0.00007729405,0.0007527377,0.0003620823,0.000115673],"category_scores_gemma":[0.00007909744,0.0004933762,0.0004375126,0.0002987025,0.000143672,0.000008310256,0.00007683224,0.0002336833,0.00003295313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005648764,"about_ca_system_score_gemma":0.0001677426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007409851,"about_ca_topic_score_gemma":0.0000717154,"domain_scores_codex":[0.9970209,0.00009491153,0.0004727003,0.0008993635,0.0004926557,0.001019489],"domain_scores_gemma":[0.998057,0.00005343505,0.0001262186,0.001186551,0.0003002118,0.0002765627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004378149,0.0003622404,0.00006143538,0.000009183315,0.0003854917,0.00002178112,0.0001275674,0.0001478795,0.9746284,0.0002123917,0.0004595746,0.01920593],"study_design_scores_gemma":[0.005270885,0.004921298,0.000211568,0.000008306098,0.000008546113,0.00002396451,0.00003609285,0.00003616904,0.9310337,0.0003444783,0.05755647,0.0005484957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9444671,0.009276766,0.0436423,0.0004238891,0.0001462022,0.001467054,0.00004831022,0.00007528331,0.0004530953],"genre_scores_gemma":[0.9899482,0.001009076,0.00255531,0.003657409,0.0005260062,0.0002617451,0.0004879769,0.0002330066,0.001321324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05709689,"threshold_uncertainty_score":0.9997518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02934023685923579,"score_gpt":0.3322104817085469,"score_spread":0.3028702448493111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}