{"id":"W1975703199","doi":"10.1038/mt.sj.6300122","title":"Engineered Human tmpk/AZT As a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy","year":2007,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Terry Fox Foundation","keywords":"Suicide gene; Jurkat cells; Prodrug; Genetic enhancement; Viral vector; Cancer research; Cytotoxic T cell; Transplantation; Biology; Cell culture; Chemistry; Molecular biology; Pharmacology; Biochemistry; Gene; T cell; Medicine; Immunology; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468422,0.0005410337,0.0002437738,0.0001870779,0.0001044961,0.0003298627,0.0002514381,0.0004236155,0.001009081],"category_scores_gemma":[0.00006519551,0.0001996073,0.0002480368,0.0001557345,0.0001900127,0.0002399489,0.0001645897,0.0007754789,0.0007296928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005525398,"about_ca_system_score_gemma":0.0003055376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003642718,"about_ca_topic_score_gemma":0.00042014,"domain_scores_codex":[0.9998522,0.00001661112,0.00001465787,0.00003604994,0.00005777876,0.00002262679],"domain_scores_gemma":[0.999961,0.000004836317,0.00001526806,0.000004293399,0.000006180484,0.000008429798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003672243,0.00002747664,0.00005394966,0.00002477512,0.000004423317,0.00004547356,0.000005831199,0.0002725917,0.9964246,0.0003772478,0.0001146588,0.002612184],"study_design_scores_gemma":[0.00002570245,0.0001445568,0.0001584907,0.000002249645,0.00001006057,0.0001746595,0.000001901138,0.001076965,0.9934022,0.000052066,0.004947205,0.000003956523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8444633,0.005836704,0.1339047,0.0008261416,0.0002936197,0.0006999614,0.001416582,0.001353868,0.01120512],"genre_scores_gemma":[0.9237996,0.002145203,0.06438173,0.0001772924,0.00003482294,0.0001950371,0.0009965822,0.0001072888,0.008162506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009081,"threshold_uncertainty_score":0.004008949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02934023685923579,"score_gpt":0.3322104817085469,"score_spread":0.3028702448493111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}