{"id":"W1975703347","doi":"10.1002/stem.210","title":"Wnt/β-Catenin Signaling Blockade Promotes Neuronal Induction and Dopaminergic Differentiation in Embryonic Stem Cells","year":2009,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Medical Research Council; Vetenskapsrådet; Grantová Agentura České Republiky; National Health and Medical Research Council; European Commission; Karolinska Institutet; Norges Forskningsråd; Akademie Věd České Republiky; Stiftelsen för Strategisk Forskning; University of Washington","keywords":"Wnt signaling pathway; Biology; Embryonic stem cell; LRP6; DKK1; Cell biology; Beta-catenin; Cellular differentiation; Stem cell; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001397228,0.0004029192,0.0003563469,0.0002894919,0.0001051238,0.0002974306,0.0001738872,0.0002275353,0.001055076],"category_scores_gemma":[0.00008935675,0.0001837352,0.0002969616,0.0001709459,0.0001682368,0.0001826856,0.0001995732,0.0006116771,0.0003051021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445008,"about_ca_system_score_gemma":0.0003069706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009038424,"about_ca_topic_score_gemma":0.001828732,"domain_scores_codex":[0.9998247,0.0000190873,0.00003791425,0.00002984394,0.0000546146,0.00003391851],"domain_scores_gemma":[0.9998877,0.00001815934,0.00002867749,0.00001111872,0.00001067281,0.00004356652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006624605,0.00004789304,0.0001409499,0.00004841394,0.000007644733,0.00005276209,0.00001362418,0.00006683965,0.9983807,0.00006772248,0.00004044627,0.001066729],"study_design_scores_gemma":[0.00002181129,0.0002515853,0.002896676,0.000007956025,0.00002066027,0.0001171715,0.00001834344,0.0006512782,0.9941294,0.00002988432,0.001852291,0.000003035543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949143,0.00158731,0.0009913633,0.00006951225,0.00002802187,0.00003103878,0.0004197736,0.00008809585,0.001870548],"genre_scores_gemma":[0.9912356,0.001891262,0.001428273,0.00005883673,0.00001026961,0.00005007485,0.0008321399,0.00002368922,0.004469858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001055076,"threshold_uncertainty_score":0.003529549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01434338005130232,"score_gpt":0.2345562226078031,"score_spread":0.2202128425565008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}