{"id":"W1975703347","doi":"10.1002/stem.210","title":"Wnt/β-Catenin Signaling Blockade Promotes Neuronal Induction and Dopaminergic Differentiation in Embryonic Stem Cells","year":2009,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Medical Research Council; Vetenskapsrådet; Grantová Agentura České Republiky; National Health and Medical Research Council; European Commission; Karolinska Institutet; Norges Forskningsråd; Akademie Věd České Republiky; Stiftelsen för Strategisk Forskning; University of Washington","keywords":"Wnt signaling pathway; Biology; Embryonic stem cell; LRP6; DKK1; Cell biology; Beta-catenin; Cellular differentiation; Stem cell; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002806535,0.0002491928,0.0002244324,0.0001554092,0.00009115154,0.00007192875,0.0001853812,0.0002166226,0.0000122175],"category_scores_gemma":[0.00000311219,0.0002408006,0.0000703188,0.0001940818,0.00005374903,0.00001439991,0.0001005221,0.0002339809,0.00002240857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003997473,"about_ca_system_score_gemma":0.00005765055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001198417,"about_ca_topic_score_gemma":0.0000121768,"domain_scores_codex":[0.9981223,0.000191886,0.0003251556,0.0006140542,0.0002914479,0.0004551962],"domain_scores_gemma":[0.9994612,0.00002222345,0.0001236938,0.0002017637,0.00006485981,0.0001262583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007483787,0.0001063631,0.000342376,0.00005307942,0.00001582166,0.000009670733,0.00006899307,0.0002431318,0.9941446,0.000006334217,0.00008523686,0.004849618],"study_design_scores_gemma":[0.0007174844,0.0004515472,0.002362887,0.00004012172,0.00001471595,0.0000130205,0.00007673864,0.000926432,0.9948218,0.00002977169,0.0002967026,0.0002487873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981218,0.0007550242,0.0001176471,0.0001982284,0.0001885073,0.0004365892,0.00001029303,0.00002162901,0.0001502844],"genre_scores_gemma":[0.9968061,0.0002476219,0.00005080249,0.00004149753,0.0001700318,0.00001593546,0.00003735318,0.00002674459,0.002603936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004600831,"threshold_uncertainty_score":0.9819562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01434338005130232,"score_gpt":0.2345562226078031,"score_spread":0.2202128425565008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}