{"id":"W1975727747","doi":"10.1016/j.jaci.2009.08.007","title":"Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency","year":2009,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; Université de Sherbrooke","keywords":"Icatibant; Bradykinin; Receptor; Kininogen; C1-inhibitor; In vivo; Pharmacology; Hereditary angioedema; Angioedema; Vascular permeability; Chemistry; Receptor antagonist; Medicine; Internal medicine; Immunology; Antagonist; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005631582,0.0006771681,0.0006739544,0.0006316141,0.0004619837,0.000931695,0.000576885,0.001122274,0.002366099],"category_scores_gemma":[0.0003304364,0.0001981022,0.0004707043,0.0002034006,0.0007361096,0.0007447305,0.0003555198,0.00181613,0.0003276165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000470404,"about_ca_system_score_gemma":0.0003959402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001949096,"about_ca_topic_score_gemma":0.0002798076,"domain_scores_codex":[0.9998709,0.00003818534,0.00001088343,0.00001550495,0.00002530471,0.00003927113],"domain_scores_gemma":[0.9998972,0.00004708154,0.00001673496,0.00000713524,0.00001193662,0.00001995936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009585069,0.003600483,0.008383567,0.003618678,0.00032939,0.0456902,0.0005581999,0.002789009,0.3512382,0.07157689,0.02434912,0.4782812],"study_design_scores_gemma":[0.01258805,0.01655995,0.03629216,0.001750359,0.001774457,0.2605173,0.0010306,0.02346645,0.283404,0.07808559,0.2842614,0.0002697805],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4498729,0.4432097,0.03481269,0.02856157,0.002452691,0.000566572,0.0002962525,0.00050233,0.03972542],"genre_scores_gemma":[0.854303,0.1171325,0.01456275,0.004123245,0.004534415,0.0005044831,0.0002173873,0.00002852752,0.004593629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002366099,"threshold_uncertainty_score":0.007915378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07610899965384724,"score_gpt":0.2940553777397415,"score_spread":0.2179463780858943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}