{"id":"W1975727747","doi":"10.1016/j.jaci.2009.08.007","title":"Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency","year":2009,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; Université de Sherbrooke","keywords":"Icatibant; Bradykinin; Receptor; Kininogen; C1-inhibitor; In vivo; Pharmacology; Hereditary angioedema; Angioedema; Vascular permeability; Chemistry; Receptor antagonist; Medicine; Internal medicine; Immunology; Antagonist; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006507761,0.0001725837,0.0005885443,0.0001226601,0.0001036675,0.00002104353,0.00009124089,0.0002698444,0.00002259732],"category_scores_gemma":[0.0002497485,0.0001194026,0.000160568,0.0001623053,0.0001618572,0.00007278712,0.00003243715,0.0003330325,0.000002071583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002414344,"about_ca_system_score_gemma":0.0001202723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004807084,"about_ca_topic_score_gemma":0.00002608276,"domain_scores_codex":[0.9985065,0.00009081866,0.0007369878,0.0002263748,0.000179092,0.0002602099],"domain_scores_gemma":[0.9988844,0.000276199,0.0003767321,0.0001405226,0.0001362339,0.0001859482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01876901,0.01469128,0.08602695,0.00006061122,0.0151492,0.0007382543,0.006109712,0.00007256084,0.1074851,0.1362487,0.0005670841,0.6140815],"study_design_scores_gemma":[0.005981579,0.01246804,0.9724392,0.0002118049,0.0003951224,0.001169539,0.000458454,0.0001777015,0.0004582827,0.005393154,0.0006055257,0.0002416398],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864789,0.007147817,0.001185798,0.00468526,0.0001972567,0.0001368846,0.000001767096,0.0000176011,0.0001487629],"genre_scores_gemma":[0.9961436,0.0009564651,0.001041853,0.001465203,0.0001786291,0.000001259965,0.000002875133,0.00001349932,0.0001966601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8864122,"threshold_uncertainty_score":0.4869096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07610899965384724,"score_gpt":0.2940553777397415,"score_spread":0.2179463780858943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}