{"id":"W1975752841","doi":"10.3791/51712","title":"RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes","year":2014,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Ribozyme; RNA editing; RNA; Förster resonance energy transfer; Fluorophore; Computational biology; Hammerhead ribozyme; Chemistry; Biophysics; Nanotechnology; Fluorescence; Biochemistry; Cell biology; Biology; Materials science; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003268644,0.0001357276,0.0002407947,0.0001175499,0.00005921074,0.00004222155,0.0001380594,0.00008988672,0.00001635864],"category_scores_gemma":[0.0003278233,0.0001220944,0.0002058389,0.00006501347,0.000029021,0.0000170092,0.00004256105,0.0000548389,0.000001689872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002282602,"about_ca_system_score_gemma":0.00006579243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006589263,"about_ca_topic_score_gemma":9.741658e-7,"domain_scores_codex":[0.9987,0.00007321061,0.0006061102,0.0001796068,0.0002417195,0.0001993662],"domain_scores_gemma":[0.9989799,0.00001809711,0.0005384636,0.0001670686,0.0001372933,0.000159155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005689288,0.0001515785,0.001407411,0.00001495551,0.00007886472,0.00001145355,0.0002825099,0.0000612654,0.9891198,0.00003721315,0.002416551,0.00584946],"study_design_scores_gemma":[0.006497904,0.000376916,0.001518338,0.0001144278,0.00002877996,0.00002976641,0.0009448932,0.0007662654,0.9654683,0.00009688033,0.02392728,0.0002302325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918432,0.0004803682,0.005607985,0.0001180084,0.0002843211,0.0001485893,0.000003080734,0.000004801467,0.001509624],"genre_scores_gemma":[0.994988,0.0000226037,0.00324552,0.000640363,0.0006650278,0.00001404597,0.00004386245,0.00002361714,0.0003569621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02365149,"threshold_uncertainty_score":0.4978866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868571409869778,"score_gpt":0.3874344731274112,"score_spread":0.3687487590287134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}