{"id":"W1975763169","doi":"10.1093/emboj/19.7.1407","title":"The active site architecture of Pisum sativum β‐carbonic anhydrase is a mirror image of that of α‐carbonic anhydrases","year":2000,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":287,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Medical Research Council Canada; National Science Council","keywords":"Biology; Pisum; Carbonic anhydrase; Biochemistry; Alpha (finance); BETA (programming language); Sativum; Active site; Enzyme; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003186882,0.0001311792,0.0001759203,0.00003979961,0.0001278622,0.00001452108,0.000209583,0.00007059798,0.0003036754],"category_scores_gemma":[0.00005057591,0.00007512897,0.0002226696,0.0001056247,0.000312531,0.000007771147,0.00003883566,0.0002314883,0.000003048277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001171861,"about_ca_system_score_gemma":0.00009622057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004655748,"about_ca_topic_score_gemma":0.00005836479,"domain_scores_codex":[0.9989895,0.0001806268,0.0002961749,0.0001272058,0.000220713,0.0001857635],"domain_scores_gemma":[0.9991286,0.00005148247,0.000334573,0.0003201038,0.0001134712,0.00005174624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006850839,0.0000830244,0.0002982283,0.00001552506,0.0001277191,0.000001812315,0.000533583,0.00004228894,0.9925348,0.00002128904,0.001873831,0.003782814],"study_design_scores_gemma":[0.0006479986,0.0004742744,0.002594317,0.00005997936,0.00006002161,0.0001127195,0.0003111913,0.00004611944,0.9898639,0.0005173612,0.005218897,0.00009317727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953707,0.001011657,0.00007977698,0.0007794498,0.00008276144,0.0001142089,0.00005216212,0.000003100722,0.00250619],"genre_scores_gemma":[0.9980901,0.0008510915,0.00009647199,0.0001873136,0.0001076575,0.000003110652,0.00001090557,0.00001461797,0.0006386905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003689637,"threshold_uncertainty_score":0.3325033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007022061494378902,"score_gpt":0.2340265776470876,"score_spread":0.2270045161527087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}