{"id":"W1975768504","doi":"10.1016/s0006-2952(01)00720-1","title":"Identification of a 43-kDa protein in human liver cytosol that binds to the 3′-untranslated region of CYP2A6 mRNA 1 1Abbreviations: Abbreviations: 39-UTR, 39-untranslated region; CYP, cytochrome P450; EMSA, electrophoretic mobility shift assay; HBV, hepatitis B virus; HCV, hepatitis C virus; hnRNP, heterogenous nuclear ribonucleoprotein; pBS, pBluescript; PCR, polymerase chain reaction; and TBE, Tris-borate-EDTA.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; University of Guelph","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Untranslated region; Three prime untranslated region; Five prime untranslated region; CYP2A6; Messenger RNA; Cytosol; Molecular biology; Cytochrome P450; Biology; Chemistry; Biochemistry; Enzyme; CYP1A2; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008619431,0.0006119724,0.001135299,0.0005832291,0.0003503288,0.00004255713,0.0004446259,0.000611874,0.000209936],"category_scores_gemma":[0.00009509818,0.0005474046,0.000308496,0.001629299,0.0005871485,0.0002765602,0.00005177215,0.00078542,0.00002020077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003618021,"about_ca_system_score_gemma":0.0001977052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005432818,"about_ca_topic_score_gemma":0.0009215571,"domain_scores_codex":[0.9951081,0.0006162855,0.001781691,0.00106122,0.0006402892,0.0007924251],"domain_scores_gemma":[0.9975728,0.0001169401,0.0007968109,0.0007590931,0.0003901224,0.000364216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002391953,0.001453778,0.002216684,0.0004833707,0.0002699367,0.0002548388,0.001085502,0.000008487908,0.990358,0.0001670809,0.0006549112,0.0006554801],"study_design_scores_gemma":[0.004359008,0.001078372,0.03173164,0.0005877365,0.0006938989,0.0001637284,0.000067495,0.0008848924,0.9584319,0.000369423,0.001014525,0.0006173908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843791,0.005752736,0.001380247,0.002833748,0.0001463611,0.005120504,0.000206051,0.0001515687,0.00002964829],"genre_scores_gemma":[0.9892198,0.008774361,0.0001928324,0.0005368567,0.0001486906,0.0006335549,0.0003004916,0.0001046572,0.00008879694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03192609,"threshold_uncertainty_score":0.9996977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0165054109860952,"score_gpt":0.2636013363820036,"score_spread":0.2470959253959084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}