{"id":"W1975768504","doi":"10.1016/s0006-2952(01)00720-1","title":"Identification of a 43-kDa protein in human liver cytosol that binds to the 3′-untranslated region of CYP2A6 mRNA 1 1Abbreviations: Abbreviations: 39-UTR, 39-untranslated region; CYP, cytochrome P450; EMSA, electrophoretic mobility shift assay; HBV, hepatitis B virus; HCV, hepatitis C virus; hnRNP, heterogenous nuclear ribonucleoprotein; pBS, pBluescript; PCR, polymerase chain reaction; and TBE, Tris-borate-EDTA.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; University of Guelph","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Untranslated region; Three prime untranslated region; Five prime untranslated region; CYP2A6; Messenger RNA; Cytosol; Molecular biology; Cytochrome P450; Biology; Chemistry; Biochemistry; Enzyme; CYP1A2; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001767918,0.000921032,0.0005242572,0.0006909371,0.0006012024,0.000430053,0.0001892749,0.000652922,0.004789638],"category_scores_gemma":[0.0002771552,0.0003179795,0.0008352769,0.000461017,0.0002920985,0.0002951152,0.0003003216,0.0006777146,0.003823748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004144546,"about_ca_system_score_gemma":0.0004372146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000691217,"about_ca_topic_score_gemma":0.0007565074,"domain_scores_codex":[0.9998264,0.00001764704,0.000008454827,0.00006874923,0.00003714888,0.00004157708],"domain_scores_gemma":[0.9997643,0.00005125723,0.00004000332,0.00002566453,0.00003601035,0.00008280821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001239531,0.00005229998,0.0002890457,0.00008047342,0.000009964781,0.000276215,0.00005647802,0.00001972483,0.9975932,0.0001305632,0.0001656711,0.00120236],"study_design_scores_gemma":[0.0001060357,0.001011882,0.0796269,0.00007575408,0.00008945604,0.00703577,0.0002548715,0.001734532,0.8784344,0.0006034826,0.03098536,0.00004149809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9271042,0.01081184,0.04208102,0.001876408,0.000695587,0.0002851305,0.006725713,0.0007823436,0.009637843],"genre_scores_gemma":[0.8862328,0.006111172,0.04190733,0.0009811618,0.0005541176,0.000381745,0.03391335,0.0001911256,0.02972723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004789638,"threshold_uncertainty_score":0.01602298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0165054109860952,"score_gpt":0.2636013363820036,"score_spread":0.2470959253959084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}