{"id":"W1975770902","doi":"10.1021/bi701652t","title":"Alternative Catalytic Anions Differentially Modulate Human α-Amylase Activity and Specificity<sup>,</sup>","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Allosteric regulation; Chloride; Catalysis; Binding site; Active site; Enzyme kinetics; Stereochemistry; Enzyme; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002435914,0.0002139995,0.0001658538,0.00004995958,0.00006347242,0.000473946,0.0002442114,0.0002081175,0.0008052199],"category_scores_gemma":[0.0003381004,0.0001238048,0.0001187825,0.00008503131,0.0002217424,0.0001730573,0.0001595213,0.0002849911,0.0002157239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002374401,"about_ca_system_score_gemma":0.0001387466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004599335,"about_ca_topic_score_gemma":0.0006801413,"domain_scores_codex":[0.9998562,0.00003631856,0.00001804223,0.00003207077,0.00003580402,0.00002159105],"domain_scores_gemma":[0.999855,0.0000452574,0.00004036459,0.0000134065,0.00002425665,0.00002156318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002201316,0.000008282184,0.0002512302,0.00001718262,0.0000026501,0.00002483001,0.00001137686,0.00004444405,0.9986323,0.00004465605,0.00001794947,0.0007250162],"study_design_scores_gemma":[0.000016243,0.0001346036,0.001756268,0.000001596525,0.000006665155,0.0001180695,0.00001995972,0.0004919863,0.9965214,0.00003405645,0.0008962928,0.000002903128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971542,0.0005216312,0.001438631,0.00007026341,0.00001711212,0.00001169201,0.0001299899,0.00004121416,0.0006152199],"genre_scores_gemma":[0.9962392,0.0003137887,0.002176085,0.00008701557,0.000007781492,0.0000156327,0.0002269167,0.00002772002,0.0009058312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008052199,"threshold_uncertainty_score":0.002693772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01522710030924991,"score_gpt":0.2399042161948327,"score_spread":0.2246771158855828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}