{"id":"W1975783060","doi":"10.1158/1535-7163.targ-13-b282","title":"Abstract B282: The PLK-4 inhibitor CFI-400945 reduces tumor growth in patient-derived pancreatic xenografts.","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Gemcitabine; Pancreatic cancer; Medicine; Internal medicine; Cancer research; Metastasis; Oncology; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001061276,0.0003321576,0.0002456506,0.00006453206,0.0001104472,0.00009492822,0.0004026224,0.0001754499,0.00006775458],"category_scores_gemma":[0.00001986734,0.0002576078,0.0001489522,0.0002162703,0.000159088,0.00001210162,0.0001263552,0.0002514833,0.00002509637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005499493,"about_ca_system_score_gemma":0.0001437907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004392395,"about_ca_topic_score_gemma":0.0001209179,"domain_scores_codex":[0.9983087,0.0001020595,0.0003924631,0.0004607404,0.0002263269,0.0005097591],"domain_scores_gemma":[0.9990833,0.00001766191,0.0001656981,0.0004856311,0.0001571651,0.00009057796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004258654,0.000103319,0.001103316,0.00002418221,0.000148422,0.00001292433,0.0002481955,0.00006925366,0.9906801,0.00002795835,0.0006100162,0.006929713],"study_design_scores_gemma":[0.0006121651,0.0001675064,0.004926661,0.00005786592,0.00006087197,0.00001301983,0.0003164696,0.00008575207,0.9833144,0.0001762606,0.009871556,0.0003975053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912008,0.006342459,0.0001792909,0.000838773,0.0003036062,0.0007042122,0.00003206725,0.00002225071,0.0003765644],"genre_scores_gemma":[0.9931191,0.001442843,0.0002474241,0.004434428,0.0001990454,0.0003533316,0.00007407385,0.00007155281,0.00005821539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00926154,"threshold_uncertainty_score":0.9999876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009383804395736776,"score_gpt":0.235575805621911,"score_spread":0.2261920012261742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}