{"id":"W1975880030","doi":"10.1126/science.1189015","title":"Genotype to Phenotype: A Complex Problem","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":436,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute of Neurological Disorders and Stroke; Howard Hughes Medical Institute","keywords":"Biology; Phenotype; Genetics; Gene; Genome; Strain (injury); Genotype; Saccharomyces cerevisiae; Genetic variation; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000303433,0.00006261742,0.0000444674,0.0000501294,0.0001505516,0.00005128508,0.0005088415,0.00003669665,0.000106785],"category_scores_gemma":[0.0001031811,0.00005313507,0.00001853557,0.0003283545,0.0002735206,0.000002344435,0.0002982747,0.00008695752,0.0002480413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004689087,"about_ca_system_score_gemma":0.0002045349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001086951,"about_ca_topic_score_gemma":0.00008291704,"domain_scores_codex":[0.9990478,0.000007798109,0.00006733817,0.0003154656,0.0002560677,0.0003055238],"domain_scores_gemma":[0.9993033,0.000002736552,0.00001215136,0.0003215292,0.0001621121,0.0001981448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001237002,0.00001562567,0.0006548215,0.000002739089,0.000001170836,4.637997e-7,0.0000265219,0.00001731217,0.9924352,0.0002892969,0.0008586448,0.005685804],"study_design_scores_gemma":[0.000100161,0.0001897486,0.02237959,0.000001724661,0.000001025624,0.000006101129,0.00001148606,0.0001131705,0.7862402,0.0002497279,0.1905847,0.0001222732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844011,0.00003555229,0.000401582,0.0004375968,0.0001703902,0.0001473303,0.000006011932,0.000008518206,0.01439192],"genre_scores_gemma":[0.9861124,0.000004259772,0.01202454,0.0003442278,0.0001552654,0.000009993607,0.000005298386,0.000006580136,0.001337447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.206195,"threshold_uncertainty_score":0.3188152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01744721926483811,"score_gpt":0.3094057994521741,"score_spread":0.2919585801873359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}