{"id":"W1975880030","doi":"10.1126/science.1189015","title":"Genotype to Phenotype: A Complex Problem","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":436,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute of Neurological Disorders and Stroke; Howard Hughes Medical Institute","keywords":"Biology; Phenotype; Genetics; Gene; Genome; Strain (injury); Genotype; Saccharomyces cerevisiae; Genetic variation; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01927043,0.001315483,0.004134587,0.0033634,0.00146469,0.004218986,0.003594617,0.00334432,0.004249132],"category_scores_gemma":[0.08348516,0.001089845,0.0009846906,0.003786436,0.006992717,0.005680582,0.00354741,0.004676195,0.001717252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001513409,"about_ca_system_score_gemma":0.001233219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001590107,"about_ca_topic_score_gemma":0.001392038,"domain_scores_codex":[0.9763817,0.0128304,0.001778888,0.005045446,0.003498561,0.0004649907],"domain_scores_gemma":[0.8498433,0.1298269,0.005245833,0.009238645,0.004598713,0.001246651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000411247,0.0007097252,0.1211201,0.002526473,0.001811117,0.006746252,0.002796149,0.0235005,0.01851806,0.1468399,0.03811931,0.6369012],"study_design_scores_gemma":[0.0001223087,0.0002466202,0.06486169,0.0007723417,0.0005130351,0.01484959,0.002790241,0.03773686,0.004331717,0.8255891,0.04779857,0.0003879199],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1805264,0.02481431,0.7127752,0.05241199,0.001835997,0.0004152637,0.003522051,0.002662477,0.02103633],"genre_scores_gemma":[0.7271383,0.01777629,0.2144191,0.02628995,0.00249104,0.0008187704,0.002130862,0.002683027,0.006252781],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01927043,"threshold_uncertainty_score":0.1019129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01744721926483811,"score_gpt":0.3094057994521741,"score_spread":0.2919585801873359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}