{"id":"W1975998126","doi":"10.1159/000357953","title":"Anti-Inflammatory Activity of Ezetimibe by Regulating NF-κB/MAPK Pathway in THP-1 Macrophages","year":2014,"lang":"en","type":"article","venue":"Pharmacology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"Ezetimibe; THP1 cell line; NF-κB; Tumor necrosis factor alpha; Phorbol; Chemistry; MAPK/ERK pathway; Inflammation; Protein kinase A; Molecular biology; Signal transduction; Pharmacology; Cell biology; Biology; Kinase; Protein kinase C; Endocrinology; Biochemistry; Cholesterol; Cell culture; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178903,0.0003708625,0.0004395703,0.0002298501,0.0001699103,0.000218075,0.0001596027,0.0001914222,0.001156578],"category_scores_gemma":[0.00009223342,0.0001236808,0.0002254402,0.0001654499,0.0001901261,0.0001810927,0.0001391359,0.0005697357,0.0003578871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001676814,"about_ca_system_score_gemma":0.0001771678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002720011,"about_ca_topic_score_gemma":0.0004749869,"domain_scores_codex":[0.9999198,0.00001422921,0.00001245471,0.00001277507,0.0000167989,0.00002402642],"domain_scores_gemma":[0.9999589,0.000007471691,0.00001090815,0.000005054394,0.000007601348,0.00001001904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005903995,0.00006218834,0.0001097001,0.00008687767,0.00001029831,0.00004028037,0.00001008187,0.00005169267,0.996988,0.00003703854,0.00008625495,0.001927027],"study_design_scores_gemma":[0.0001017172,0.0007234855,0.003424751,0.000007086838,0.00003588917,0.0001496346,0.00002463274,0.0005492404,0.9913005,0.00005131017,0.003625981,0.000005760641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864256,0.006936403,0.003190449,0.000355871,0.0001376078,0.00005022423,0.0008933143,0.0001471958,0.001863196],"genre_scores_gemma":[0.9846835,0.004983032,0.005409285,0.0002649626,0.00007240616,0.0001193051,0.001438803,0.00002628973,0.003002539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001156578,"threshold_uncertainty_score":0.003869116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009011686549804733,"score_gpt":0.2680619089631701,"score_spread":0.2590502224133653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}