{"id":"W1976011051","doi":"10.1073/pnas.0905965106","title":"Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to <i>c-Myc</i> -induced lymphomas","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institutes of Health; Canada Research Chairs; Leukemia Research Foundation","keywords":"MSH2; DNA; Progenitor cell; Biology; DNA repair; Cancer research; Genetics; Molecular biology; Cell biology; Computational biology; Chemistry; DNA mismatch repair; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009345715,0.0002911846,0.0002121633,0.0002436653,0.0001109846,0.0002460496,0.0001849083,0.0002309674,0.001150708],"category_scores_gemma":[0.00009103509,0.000126412,0.0001080109,0.00008223554,0.0002209392,0.0001052044,0.000169478,0.0004424803,0.0001788292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001468153,"about_ca_system_score_gemma":0.0001406882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002849865,"about_ca_topic_score_gemma":0.0005864168,"domain_scores_codex":[0.9999052,0.00001535751,0.000007023341,0.0000171198,0.00002359055,0.00003163762],"domain_scores_gemma":[0.9998461,0.00001725773,0.00004321715,0.0000148973,0.000009169481,0.00006928597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001243342,0.00002843545,0.0001566039,0.00001182243,0.000003769444,0.00002351723,0.000006164152,0.00003690205,0.9988673,0.00004925933,0.0000176035,0.000674288],"study_design_scores_gemma":[0.00001845299,0.0006159725,0.002442229,0.0000037015,0.00001048686,0.0002135105,0.00001579684,0.0003466004,0.9951439,0.0000275548,0.001159622,0.000002244152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985719,0.0002920614,0.000523549,0.00003033772,0.000007177993,0.000008274215,0.00006052394,0.00004353634,0.0004626393],"genre_scores_gemma":[0.9977277,0.0002238663,0.0004014125,0.00002148902,0.000005824237,0.00001097217,0.0001527986,0.00001507757,0.001440878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001150708,"threshold_uncertainty_score":0.003849447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878942620533547,"score_gpt":0.2775015645599677,"score_spread":0.2587121383546322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}