{"id":"W1976015442","doi":"10.1073/pnas.1418852112","title":"Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Western University","funders":"Office of Extramural Research, National Institutes of Health; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Austrian Science Fund; Government of Canada; Deutsche Forschungsgemeinschaft; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"STIM1; ORAI1; Endoplasmic reticulum; Cell biology; Coiled coil; Mutant; Mutation; Cytoplasm; Biology; Chemistry; Biophysics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001894694,0.00009551461,0.0001584477,0.000277475,0.0001211007,0.00001873935,0.0005071459,0.00007377112,0.000008061978],"category_scores_gemma":[0.002285099,0.00005420337,0.00005809253,0.001151065,0.0006906008,0.0004644788,0.00009836836,0.0001771452,0.000001072973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007998242,"about_ca_system_score_gemma":0.00006370358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002534334,"about_ca_topic_score_gemma":8.649781e-7,"domain_scores_codex":[0.9974928,0.00003625432,0.0005013099,0.0002404167,0.001583817,0.0001453927],"domain_scores_gemma":[0.9987184,0.000313046,0.0006066101,0.000009093927,0.0003297123,0.00002312308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001942006,0.0003813725,0.008702526,0.00003664432,0.000003388217,1.383353e-8,0.003820027,0.01417765,0.9598917,0.01159441,0.0002458731,0.0009521547],"study_design_scores_gemma":[0.0009333908,0.0000797816,0.05424869,0.0001381675,0.000003140742,0.000003337946,0.002096995,0.01027464,0.912844,0.01922175,0.00006377505,0.00009230858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970735,0.00002845919,0.000001660994,0.001362978,0.00007949659,0.0002926683,0.00001284148,0.000004845709,0.001143489],"genre_scores_gemma":[0.9995955,0.000009344821,0.0001509719,0.0001416758,0.00002729225,0.00001673916,3.334719e-7,0.000003664735,0.00005447015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04704771,"threshold_uncertainty_score":0.2735642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06158258619858588,"score_gpt":0.2990871493562064,"score_spread":0.2375045631576205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}