{"id":"W1976015442","doi":"10.1073/pnas.1418852112","title":"Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Western University","funders":"Office of Extramural Research, National Institutes of Health; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Austrian Science Fund; Government of Canada; Deutsche Forschungsgemeinschaft; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"STIM1; ORAI1; Endoplasmic reticulum; Cell biology; Coiled coil; Mutant; Mutation; Cytoplasm; Biology; Chemistry; Biophysics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001170946,0.0009209272,0.000280968,0.0003778199,0.0003345301,0.0001916918,0.0001681641,0.0007539446,0.002009029],"category_scores_gemma":[0.0002778198,0.0001138512,0.000422928,0.0002960742,0.0003793616,0.0001037392,0.0002812336,0.000325641,0.0004140216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001723517,"about_ca_system_score_gemma":0.0001743328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006744068,"about_ca_topic_score_gemma":0.0006898203,"domain_scores_codex":[0.9998966,0.00001439893,0.0000150451,0.00003390216,0.00001923334,0.00002084407],"domain_scores_gemma":[0.9998437,0.00004109737,0.00004535726,0.00001056321,0.000009252946,0.00004991031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009397714,0.000138522,0.03337399,0.0001103433,0.000162079,0.1095745,0.0004152419,0.0005994997,0.8397155,0.001117075,0.001044296,0.01280915],"study_design_scores_gemma":[0.0002575495,0.001020702,0.2927059,0.00008357503,0.0002787445,0.4394056,0.0002536697,0.003611357,0.248611,0.001075885,0.01259695,0.00009892716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970254,0.0003031092,0.001204369,0.00008597428,0.00002520836,0.00002240317,0.0003845901,0.0000825586,0.0008663036],"genre_scores_gemma":[0.9985844,0.0001230738,0.0006107679,0.00005562826,0.00001841064,0.000009958837,0.0002309142,0.00001178262,0.0003549385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002009029,"threshold_uncertainty_score":0.006720901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06158258619858588,"score_gpt":0.2990871493562064,"score_spread":0.2375045631576205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}