{"id":"W1976022788","doi":"10.1186/1471-2407-14-177","title":"Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens","year":2014,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":309,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"BC Cancer Agency","keywords":"Breast cancer; Reproducibility; Medicine; Oncology; Internal medicine; Surgical oncology; Cancer; Pathology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01343136,0.0009719682,0.00058468,0.002049105,0.001034866,0.0009784522,0.001496689,0.00115791,0.001156195],"category_scores_gemma":[0.01133129,0.00065668,0.0005944219,0.0009473713,0.001464646,0.0003915237,0.0009490488,0.0007613752,0.0009049566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00113735,"about_ca_system_score_gemma":0.001442564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001916507,"about_ca_topic_score_gemma":0.004452781,"domain_scores_codex":[0.9762654,0.005780832,0.001543797,0.004024927,0.01173627,0.0006488309],"domain_scores_gemma":[0.9913663,0.002376084,0.001272302,0.001962562,0.002848333,0.0001743459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005249742,0.0002464945,0.0158898,0.0002231803,0.000156894,0.0001114044,0.0003275831,0.001802937,0.9594438,0.0004494267,0.0008529486,0.01997058],"study_design_scores_gemma":[0.00005196404,0.001052975,0.04433678,0.00004768889,0.0001507365,0.0009162102,0.00006826976,0.01151079,0.9371933,0.0002184874,0.004393282,0.00005960788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6520178,0.001642393,0.3344992,0.0004496925,0.0002225357,0.001628148,0.002184245,0.002777796,0.004578206],"genre_scores_gemma":[0.6228924,0.0004828679,0.3625637,0.0006200442,0.00009172495,0.004153152,0.004857555,0.0004098046,0.003928786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01343136,"threshold_uncertainty_score":0.07103264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071389454951906,"score_gpt":0.256795952167091,"score_spread":0.2460820576175719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}