{"id":"W1976046290","doi":"10.2337/db11-0948","title":"Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells","year":2011,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Medical Research Council; Australian Diabetes Society","keywords":"Biology; Central tolerance; Peripheral tolerance; Immunology; T cell; Transgene; T-cell receptor; NOD mice; Nod; Autoimmunity; Antigen; Genetically modified mouse; Immune tolerance; Immune system; Endocrinology; Diabetes mellitus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001994914,0.0005353678,0.0003277424,0.0003117563,0.0001459291,0.0003680256,0.000228803,0.0002970474,0.001553307],"category_scores_gemma":[0.0001712505,0.0002822961,0.000228074,0.0001620398,0.0002700388,0.0002613814,0.0002279905,0.001057828,0.000444666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001460949,"about_ca_system_score_gemma":0.0001895903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002081417,"about_ca_topic_score_gemma":0.0002973506,"domain_scores_codex":[0.9998026,0.00002378216,0.0000240524,0.00005214767,0.00003551603,0.00006188998],"domain_scores_gemma":[0.9995634,0.00003960694,0.0001537693,0.00006481915,0.00002739866,0.0001511044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002760959,0.00004793606,0.0002987325,0.00002269394,0.0000044292,0.00007312089,0.0000148822,0.00003637128,0.9979499,0.0000600465,0.00001883478,0.001196919],"study_design_scores_gemma":[0.0002391316,0.002110828,0.02241803,0.00003737475,0.00006943423,0.002287752,0.00006411966,0.001251915,0.9685938,0.0003006101,0.002609969,0.00001706356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961208,0.0007691472,0.001476919,0.00005635525,0.00002240702,0.00001444957,0.0003200599,0.0001413343,0.001078488],"genre_scores_gemma":[0.9949861,0.0006094679,0.0009353167,0.00006007034,0.00001743671,0.00003704997,0.000486579,0.00006352139,0.002804488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553307,"threshold_uncertainty_score":0.005196273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01500077557648974,"score_gpt":0.2097578209918683,"score_spread":0.1947570454153786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}