{"id":"W1976046875","doi":"10.1016/j.semcdb.2010.03.006","title":"Protein quality control in the ER: The recognition of misfolded proteins","year":2010,"lang":"en","type":"review","venue":"Seminars in Cell and Developmental Biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":279,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Calnexin; Glycan; Protein disulfide-isomerase; Foldase; Endoplasmic reticulum; Protein folding; Glycoprotein; Chaperone (clinical); Biochemistry; Endoplasmic-reticulum-associated protein degradation; Chemistry; Biology; Cell biology; Unfolded protein response; Calreticulin; GroEL; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006835351,0.0002609275,0.0005454594,0.00005818688,0.0000515326,0.0000110606,0.0002988924,0.0004489929,0.00001385071],"category_scores_gemma":[0.0001590899,0.0001415639,0.0001256079,0.0001121545,0.00027525,0.000002060997,0.0001050946,0.0003367506,0.000004338809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001596553,"about_ca_system_score_gemma":0.0002355836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007337294,"about_ca_topic_score_gemma":0.0001715672,"domain_scores_codex":[0.9982154,0.0005229907,0.0005680048,0.0003820851,0.00007591293,0.0002355648],"domain_scores_gemma":[0.9993149,0.0001411551,0.0002569872,0.0002263128,0.00002330373,0.00003731083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001343688,0.0002894139,0.001414891,0.003042599,0.00004504861,0.00001405766,0.0002522143,6.303942e-8,0.02261855,0.00006253942,0.0002035079,0.9719228],"study_design_scores_gemma":[0.001756382,0.000339488,0.0002708309,0.003046281,0.0001039088,0.00008526743,0.0007715999,0.000001085761,0.01042598,0.0005354007,0.9820054,0.0006584214],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09886684,0.8977182,0.000007245234,0.00004065859,0.00007442075,0.0017318,0.0001739481,0.00000265061,0.001384264],"genre_scores_gemma":[0.04259205,0.9554814,0.0003466159,0.0001213884,0.00004846834,0.0007322769,0.0005583795,0.00001472864,0.0001046731],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9818019,"threshold_uncertainty_score":0.5772808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0218040386719199,"score_gpt":0.2959096282622405,"score_spread":0.2741055895903206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}