{"id":"W1976053513","doi":"10.1002/bit.22113","title":"An efficient and scalable process for helper‐dependent adenoviral vector production using polyethylenimine‐adenofection","year":2008,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal; National Research Council Canada; Université de Montréal; Biotechnology Research Institute","funders":"","keywords":"Polyethylenimine; Transfection; Plasmid; Cell culture; Biology; Virology; Viral vector; Vector (molecular biology); Computational biology; Recombinant DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479563,0.0001469237,0.0001182395,0.0001410253,0.0002159087,0.00001204364,0.00008744266,0.0003243889,0.000001359516],"category_scores_gemma":[0.00003643638,0.000144035,0.00002270522,0.0001256537,0.0001604415,0.000007954926,0.00004241359,0.0001220445,4.638624e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000203906,"about_ca_system_score_gemma":0.00003549314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008483169,"about_ca_topic_score_gemma":0.00001318201,"domain_scores_codex":[0.9990904,0.00001587078,0.0001179812,0.000421801,0.00007789323,0.0002760696],"domain_scores_gemma":[0.9996573,0.000003759368,0.00003130891,0.0001973497,0.00005080546,0.00005947487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003708255,0.00004943242,0.0003562373,0.00005071692,0.00002986665,0.000001729345,0.00003758727,0.003523872,0.9941474,0.00001223939,0.000003809439,0.001416258],"study_design_scores_gemma":[0.0003904805,0.001791137,0.0004059463,0.00001162745,0.00001301584,0.0002174585,0.00007262317,0.01369415,0.9831253,0.000005134408,0.00009732095,0.0001758508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912803,0.002108097,0.005811712,0.0002360744,0.0001337062,0.000346597,0.000008543779,0.00007348901,0.000001445311],"genre_scores_gemma":[0.998612,0.0003180662,0.0007509303,0.00001433078,0.0001905449,0.00003619394,0.00001625563,0.00002532859,0.00003633515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01102217,"threshold_uncertainty_score":0.5873576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02086661642782403,"score_gpt":0.2827615633239549,"score_spread":0.2618949468961309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}