{"id":"W1976053513","doi":"10.1002/bit.22113","title":"An efficient and scalable process for helper‐dependent adenoviral vector production using polyethylenimine‐adenofection","year":2008,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal; National Research Council Canada; Université de Montréal; Biotechnology Research Institute","funders":"","keywords":"Polyethylenimine; Transfection; Plasmid; Cell culture; Biology; Virology; Viral vector; Vector (molecular biology); Computational biology; Recombinant DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007806136,0.0007460819,0.0005902261,0.0005478637,0.0002632782,0.0006591848,0.0004589162,0.0006708858,0.001233641],"category_scores_gemma":[0.000537493,0.000303521,0.0005736207,0.0004385524,0.0003692794,0.0004746676,0.0005224449,0.001459746,0.001427344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002974751,"about_ca_system_score_gemma":0.0005212553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002993271,"about_ca_topic_score_gemma":0.0004946325,"domain_scores_codex":[0.9993376,0.00007875272,0.00006671449,0.0001737275,0.0002941853,0.00004900521],"domain_scores_gemma":[0.9997807,0.0000749301,0.00005255556,0.00003527095,0.00003425709,0.00002232689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002032023,0.00003153047,0.00006114809,0.00006876231,0.000004255693,0.0000338032,0.00001580645,0.00009432789,0.9933327,0.0001171279,0.00006374399,0.006156464],"study_design_scores_gemma":[0.00001164044,0.0002618517,0.0007376046,0.00001305753,0.00001721536,0.0002866492,0.00001104909,0.001323025,0.9914535,0.0001336173,0.005733536,0.00001729873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3281944,0.008757175,0.6517659,0.0002372755,0.0003289671,0.002165955,0.001433368,0.00227446,0.004842358],"genre_scores_gemma":[0.4761079,0.007856205,0.5048773,0.0001932859,0.0000854843,0.001596342,0.003200948,0.0002311674,0.005851287],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001233641,"threshold_uncertainty_score":0.004128337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02086661642782403,"score_gpt":0.2827615633239549,"score_spread":0.2618949468961309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}