{"id":"W1976060118","doi":"10.1007/s00280-011-1556-5","title":"Genetic variation in radiation and platinum pathways predicts severe acute radiation toxicity in patients with esophageal adenocarcinoma treated with cisplatin-based preoperative radiochemotherapy: results from the Eastern Cooperative Oncology Group","year":2011,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Medicine; Single-nucleotide polymorphism; Oncology; Internal medicine; Toxicity; Cisplatin; Radiation therapy; Esophageal cancer; Gastroenterology; Chemotherapy; Genotype; Cancer; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003604239,0.0002796108,0.0003499762,0.0002991987,0.0003517483,0.0004866577,0.0002837151,0.0003776662,0.0005733436],"category_scores_gemma":[0.001270918,0.0002016828,0.0005803779,0.0006515668,0.0003035708,0.0002293055,0.0002638527,0.0004479023,0.00009579883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003190198,"about_ca_system_score_gemma":0.0002652124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00308429,"about_ca_topic_score_gemma":0.004508485,"domain_scores_codex":[0.9997163,0.00009486928,0.00003237905,0.00007289143,0.00004596745,0.0000374742],"domain_scores_gemma":[0.9993324,0.0002215729,0.0002021085,0.00006983272,0.00006128442,0.0001128287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008296034,0.00006674886,0.9950933,0.00000645732,0.0002217836,0.00007219317,0.00004722387,0.0001255371,0.001517568,0.00001063113,0.00008758064,0.001921394],"study_design_scores_gemma":[0.00003530072,0.0001910961,0.998914,0.000001543562,0.0001136702,0.0001877656,0.00005617454,0.0001711622,0.0001888716,0.00002306278,0.0001144683,0.000002960113],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995498,0.0001167491,0.00004678356,0.00003574304,0.00000375326,0.000003415812,0.0001227664,0.00000147268,0.0001194927],"genre_scores_gemma":[0.9995762,0.00005144311,0.00005128651,0.00003135464,0.000006009083,0.000002819163,0.00020051,0.000001995227,0.00007852798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00308429,"threshold_uncertainty_score":0.006132722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01862893161663249,"score_gpt":0.273451616127499,"score_spread":0.2548226845108665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}