{"id":"W1976066099","doi":"10.1002/humu.20732","title":"Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine","year":2008,"lang":"en","type":"article","venue":"Human Mutation","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Biology; Haplotype; Single-nucleotide polymorphism; Candidate gene; Genetics; Gene; Genetic association; Genome-wide association study; Computational biology; Genetic marker; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004722034,0.0002013076,0.0003512528,0.0005675269,0.0001854132,0.0002935553,0.0001219047,0.0001974851,0.0009022309],"category_scores_gemma":[0.0006884231,0.00006784299,0.0002433484,0.0004533004,0.0001227503,0.00008396689,0.0002148627,0.0002469568,0.00008959686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001559636,"about_ca_system_score_gemma":0.0002262814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001115559,"about_ca_topic_score_gemma":0.001425561,"domain_scores_codex":[0.9998719,0.00006106855,0.000007016065,0.00002281854,0.00002499059,0.000012242],"domain_scores_gemma":[0.9998065,0.0001043317,0.00002209868,0.00002438829,0.0000102266,0.00003257618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002261209,0.0004115194,0.2484271,0.0001379806,0.0002702244,0.001659687,0.0002442605,0.003889499,0.5250612,0.001011251,0.0007047841,0.2159213],"study_design_scores_gemma":[0.000303383,0.00202151,0.8333796,0.00006362014,0.0007810191,0.003266684,0.0003057288,0.01806971,0.129507,0.002575436,0.009667247,0.00005921528],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929724,0.001279911,0.004466433,0.0002413451,0.000006759632,0.0000337325,0.000232567,0.00003783345,0.000729068],"genre_scores_gemma":[0.992426,0.001076402,0.005914883,0.00005471108,0.000009611708,0.00001386866,0.0001737342,0.000006052849,0.0003247529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001115559,"threshold_uncertainty_score":0.00301826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01047954266444915,"score_gpt":0.273245338771791,"score_spread":0.2627657961073419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}