{"id":"W1976111313","doi":"10.1164/rccm.201403-0586oc","title":"A Functional Synonymous Coding Variant in the <i>IL1RN</i> Gene Is Associated with Survival in Septic Shock","year":2014,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; University of Pennsylvania; National Institutes of Health; National Center for Advancing Translational Sciences; Pennsylvania Department of Health; National Center for Research Resources; American Heart Association","keywords":"Medicine; Septic shock; Gene; Coding (social sciences); Shock (circulatory); Intensive care medicine; Sepsis; Genetics; Internal medicine; Statistics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001671855,0.0001203518,0.0004030332,0.0001743506,0.00008883438,0.00000936643,0.0001132354,0.00006859146,0.00007758562],"category_scores_gemma":[0.001190505,0.00007027225,0.00003766696,0.0002699575,0.0007130424,0.00008261572,0.00001477749,0.0004828927,0.000003285164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004645283,"about_ca_system_score_gemma":0.00008707149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003088898,"about_ca_topic_score_gemma":0.00002977728,"domain_scores_codex":[0.9980098,0.001092317,0.0004259804,0.0001227771,0.0001273332,0.0002217869],"domain_scores_gemma":[0.9981238,0.001393968,0.0001546336,0.0001063131,0.0001904053,0.00003083509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02126356,0.001336162,0.1835159,0.0003978088,0.001183552,0.006503503,0.06884471,0.0001537341,0.4348791,0.02350223,0.006531357,0.2518883],"study_design_scores_gemma":[0.03191468,0.06060963,0.688086,0.003626324,0.001117081,0.01047665,0.1427514,0.0001175562,0.01703642,0.0009605774,0.04186263,0.001441057],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941306,0.002334411,0.0005633723,0.00228794,0.0001919632,0.00006465556,0.000002097649,0.00000438282,0.0004205947],"genre_scores_gemma":[0.9969407,0.00002773597,0.00001105431,0.002902615,0.00008989979,0.000003634493,0.000004734038,0.000007224637,0.00001242605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5045701,"threshold_uncertainty_score":0.2865619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01386118833502328,"score_gpt":0.253486321871757,"score_spread":0.2396251335367337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}