{"id":"W1976116660","doi":"10.1038/srep02305","title":"Binding of disordered proteins to a protein hub","year":2013,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Photosynthetic Processes and Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Waterloo; Compute Canada","keywords":"Isothermal titration calorimetry; Interactome; Affinities; Binding affinities; Molecular dynamics; Plasma protein binding; KEAP1; Biophysics; Chemistry; Computational biology; Protein–protein interaction; Binding site; Biochemistry; Biology; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632771,0.0002241766,0.0002951048,0.0001074151,0.0003133281,0.0002585272,0.0002433899,0.0001992616,0.001138517],"category_scores_gemma":[0.0002999541,0.0001500363,0.0001954944,0.0001004276,0.0002516305,0.0002836218,0.0002705166,0.0004453067,0.0002432785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003572144,"about_ca_system_score_gemma":0.0002025077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005056884,"about_ca_topic_score_gemma":0.0006731947,"domain_scores_codex":[0.9999033,0.00001363965,0.00000576674,0.00003087413,0.00002452587,0.00002187828],"domain_scores_gemma":[0.9998386,0.00005051625,0.00003377005,0.00001670775,0.00002225609,0.00003808286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002499155,0.00005402543,0.001756554,0.0001131473,0.00003339297,0.0001862018,0.00004500094,0.00947476,0.9838958,0.001026405,0.0001418868,0.003022831],"study_design_scores_gemma":[0.00005628949,0.0003641183,0.005375546,0.00001576841,0.00004708597,0.0003850491,0.00007964927,0.04902612,0.9405372,0.001128194,0.002945701,0.00003931202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905478,0.0004696675,0.007983471,0.00005837798,0.00001491205,0.00001680308,0.00006588786,0.00006233998,0.0007807892],"genre_scores_gemma":[0.9970006,0.0001497933,0.002314823,0.00006222188,0.000003211161,0.00001109808,0.0000733025,0.00001056123,0.0003744273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001138517,"threshold_uncertainty_score":0.003808677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00684425675492843,"score_gpt":0.2233256544555135,"score_spread":0.2164813977005851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}