{"id":"W1976116660","doi":"10.1038/srep02305","title":"Binding of disordered proteins to a protein hub","year":2013,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Photosynthetic Processes and Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Waterloo; Compute Canada","keywords":"Isothermal titration calorimetry; Interactome; Affinities; Binding affinities; Molecular dynamics; Plasma protein binding; KEAP1; Biophysics; Chemistry; Computational biology; Protein–protein interaction; Binding site; Biochemistry; Biology; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003600873,0.0001006497,0.0001150709,0.00007174112,0.00009764017,0.00006984505,0.0001447715,0.00006228824,0.0001055035],"category_scores_gemma":[0.0002050382,0.00008619481,0.00006142238,0.0002187998,0.00006807983,0.000006030661,0.0001367064,0.00003326901,0.00003061647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006156974,"about_ca_system_score_gemma":0.0001195229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004919113,"about_ca_topic_score_gemma":0.00001688814,"domain_scores_codex":[0.9987577,0.00001426064,0.0002781815,0.0004947459,0.0002174925,0.0002375903],"domain_scores_gemma":[0.9989466,0.000001410048,0.0001566317,0.0006079295,0.0001707356,0.0001166746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004572756,0.00005082778,0.00005196948,0.00002754007,0.00000707131,0.00000434602,0.00005320367,0.000003639791,0.9980577,0.00003604542,0.0006753303,0.001027707],"study_design_scores_gemma":[0.0000565687,0.0001084539,0.0000310412,0.00003660188,0.000003386758,0.00002176625,0.0000729076,0.000007416477,0.976586,0.003602966,0.01936087,0.0001119711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946121,0.00003132752,0.002204123,0.0001093022,0.000563586,0.00111052,0.000003010278,0.00001270687,0.001353329],"genre_scores_gemma":[0.9909789,9.18219e-7,0.001679307,0.00001782059,0.00002762157,0.0002968011,0.00002779758,0.00001341392,0.00695745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02147169,"threshold_uncertainty_score":0.3514922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00684425675492843,"score_gpt":0.2233256544555135,"score_spread":0.2164813977005851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}