{"id":"W1976146857","doi":"10.1111/liv.12146","title":"Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen‐induced acute liver failure","year":2013,"lang":"en","type":"letter","venue":"Liver International","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Saint-Luc","funders":"","keywords":"Medicine; Liver transplantation; Intensive care medicine; Acetaminophen; Liver disease; Liver failure; Transplantation; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007181691,0.001416933,0.001606198,0.001553942,0.0005790491,0.001824467,0.00169414,0.001759539,0.003597217],"category_scores_gemma":[0.003391253,0.0004431468,0.001411706,0.0005711009,0.00136556,0.00210666,0.001384573,0.004669099,0.001570231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001152919,"about_ca_system_score_gemma":0.001899396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117171,"about_ca_topic_score_gemma":0.001306296,"domain_scores_codex":[0.996924,0.001259029,0.0003606828,0.0003617419,0.0008422369,0.000252321],"domain_scores_gemma":[0.9967356,0.0007104991,0.000631887,0.0006057871,0.0008367814,0.0004794685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002158864,0.002409508,0.002882913,0.006924264,0.0005317074,0.001312795,0.0003786502,0.002235305,0.851715,0.02174081,0.01870815,0.08900196],"study_design_scores_gemma":[0.001312843,0.01943526,0.01789053,0.003892954,0.001886255,0.006187543,0.0007239871,0.01076305,0.4505639,0.01567195,0.471305,0.0003667626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"commentary","genre_scores_codex":[0.233566,0.2524312,0.4228162,0.03508773,0.01013398,0.004016303,0.008134162,0.004905796,0.02890875],"genre_scores_gemma":[0.4855496,0.248142,0.2125994,0.009614462,0.003340597,0.007436626,0.01618708,0.0008288643,0.01630144],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.007181691,"threshold_uncertainty_score":0.03798085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1519373428368927,"score_gpt":0.4129575326626948,"score_spread":0.2610201898258021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}