{"id":"W1976146857","doi":"10.1111/liv.12146","title":"Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen‐induced acute liver failure","year":2013,"lang":"en","type":"letter","venue":"Liver International","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Saint-Luc","funders":"","keywords":"Medicine; Liver transplantation; Intensive care medicine; Acetaminophen; Liver disease; Liver failure; Transplantation; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001317515,0.000675769,0.0008570407,0.0003971903,0.0002331609,0.00007089953,0.001316722,0.002596312,0.003282667],"category_scores_gemma":[0.0003240911,0.0006530713,0.0005319714,0.0002128904,0.0002573154,0.0006096546,0.0004515457,0.005929446,0.0006645159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002613353,"about_ca_system_score_gemma":0.0004099062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001271062,"about_ca_topic_score_gemma":0.0000220746,"domain_scores_codex":[0.9948976,0.0006783907,0.001351565,0.001384782,0.0009051989,0.0007824766],"domain_scores_gemma":[0.9967076,0.0004234395,0.001177499,0.0006844855,0.0008253685,0.0001816402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001705309,0.001268031,0.0007093889,0.0007716598,0.003758863,0.0009661792,0.002073045,0.0006007394,0.1207777,0.001624286,0.8415312,0.02421359],"study_design_scores_gemma":[0.002071371,0.0005792344,0.0003339323,0.0001606172,0.0007066911,0.00008965615,0.00005347744,0.05311411,0.04543915,0.00104068,0.8953872,0.001023925],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.4274116,0.001560462,0.004485506,0.4843602,0.02082608,0.007143697,0.01021691,0.0009036547,0.04309188],"genre_scores_gemma":[0.6961676,0.004388728,0.005831844,0.2595905,0.01063869,0.0007444287,0.001523947,0.0002208192,0.0208934],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.268756,"threshold_uncertainty_score":0.9995921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1519373428368927,"score_gpt":0.4129575326626948,"score_spread":0.2610201898258021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}